Lui Michelle, Safiri Saeid, Mereke Alibek, Davletov Kairat, Mebonia Nana, Myrkassymova Akbope, Aripov Timur, Mirrakhimov Erkin, Aghayan Sargis A, Gamkrelidze Amiran, Naghavi Mohsen, Kopec Jacek A, Sarrafzadegan Nizal
School of Population & Public Health, University of British Columbia, Vancouver, Canada.
Tuberculosis and Lung Disease Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Cardiol Heart Vasc. 2021 Feb 7;33:100726. doi: 10.1016/j.ijcha.2021.100726. eCollection 2021 Apr.
The burden of ischemic heart disease (IHD) is high. There is limited information on the burden of IHD in identified high risk areas like Central Asia (CA) which is comprised of Armenia, Azerbaijan, Georgia, Kazakhstan, Kyrgyzstan, Turkmenistan, Mongolia, Uzbekistan and Tajikistan. This study addresses the burden of IHD in CA at the regional and country levels.
Using data from the latest iteration of the Global Burden of Disease Study (GBD), this study provides age-adjusted mortality, prevalence, and Disability Adjusted Life Years (DALYs) of IHD by sex in the CA region, and national levels for countries in this region from 1990 to 2017.
The CA region has a higher IHD burden than the rest of the world over the studied period. Amongst the countries within this region, age-standardized mortality and DALY rates in Uzbekistan are the highest not only in CA but worldwide, while Armenia consistently has the lowest IHD burden in CA. Unhealthy diet, high systolic blood pressure and LDL-cholesterol are the risk factors with the highest attributable IHD DALYs.
Increasing burden of IHD over time in CA can be partially explained by the economic crisis in the 1990 There is considerable variation in IHD DALY rates among countries in the CA region. The reasons for such differences are likely multifactorial such as differences in risk factors distribution, health care effectiveness, political, social and economic factors.
缺血性心脏病（IHD）负担沉重。在中亚等已确定的高风险地区，关于缺血性心脏病负担的信息有限，中亚包括亚美尼亚、阿塞拜疆、格鲁吉亚、哈萨克斯坦、吉尔吉斯斯坦、土库曼斯坦、蒙古、乌兹别克斯坦和塔吉克斯坦。本研究探讨了中亚地区及各国缺血性心脏病的负担。
利用全球疾病负担研究（GBD）最新版本的数据，本研究提供了1990年至2017年期间中亚地区按性别划分的缺血性心脏病年龄标准化死亡率、患病率和伤残调整生命年（DALYs），以及该地区各国的国家层面数据。
在研究期间，中亚地区的缺血性心脏病负担高于世界其他地区。在该地区的国家中，乌兹别克斯坦的年龄标准化死亡率和DALY率不仅在中亚最高，在全球也是最高的，而亚美尼亚在中亚的缺血性心脏病负担一直最低。不健康饮食、高收缩压和低密度脂蛋白胆固醇是导致缺血性心脏病DALYs归因最高的危险因素。
中亚地区缺血性心脏病负担随时间增加，部分原因可归结为1990年代的经济危机。中亚地区各国的缺血性心脏病DALY率存在相当大的差异。造成这种差异的原因可能是多方面的，如危险因素分布、医疗保健效果、政治、社会和经济因素的差异。
