Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco.
Cardiovasc Hematol Agents Med Chem. 2022;20(3):197-211. doi: 10.2174/1871525720666220510204624.
The study aimed to assess the antihyperglycemic activity of Pulicaria mauritanica.
Pulicaria mauritanica is a medicinal and aromatic plant used for the treatment of many diseases such as inflammation, diabetes, and intestinal disorders.
The main goals of this present paper were to confirm the antihyperglycemic capacity of aqueous extract from Pulicaria mauritanica in normoglycemic and diabetic rats over a period of time (7 days of treatment).
The effect of the aqueous extract of Pulicaria mauritanica from aerial parts (AEPM) on glucose and lipid metabolism was tested using an acute test (single dose during 6 hours) and subchronic assay (repeated oral administration for seven days) at a dose of 60 mg/kg and the serum glucose levels were measured in normoglycemic and streptozotocin(STZ)-induced diabetic rats. In addition, the glycogen content in the liver, extensor digitorum longus (EDL), and soleus was evaluated. The antioxidant activity, phytochemical screening, and quantification of some secondary metabolites of this extract were also performed.
AEPM at a dose of 60 mg/kg reduced the plasma glucose concentrations significantly in STZ-induced diabetic rats after a single oral administration (p<0.05). This lowering effect became more significant during the repeated oral administration in hyperglycemic rats (p<0.0001). Also, the findings showed that this plant exhibited a significant increase in liver and skeletal soleus muscle glycogen content in diabetic rats. AEPM revealed a remarkable antioxidant activity in addition to the presence of polyphenol compounds such as flavonoids, tannins, saponins, sterols, glucides, terpenoids, quinones, anthraquinones, and mucilage.
The study shows that AEPM exhibits antihyperglycemic activity in diabetic rats, and it increases liver and muscle glycogen content.
本研究旨在评估白头婆（Pulicaria mauritanica）的降血糖活性。
白头婆是一种药用和芳香植物，用于治疗多种疾病，如炎症、糖尿病和肠道紊乱。
本研究的主要目的是在一段时间（7 天的治疗）内证实白头婆水提物在正常血糖和糖尿病大鼠中的降血糖能力。
采用急性试验（单次给药 6 小时）和亚慢性试验（重复口服给药 7 天），在 60mg/kg 的剂量下，测试白头婆地上部分水提物（AEPM）对葡萄糖和脂质代谢的影响，并测量正常血糖和链脲佐菌素（STZ）诱导的糖尿病大鼠的血清葡萄糖水平。此外，还评估了肝、趾长伸肌（EDL）和比目鱼肌中的糖原含量。还对该提取物的抗氧化活性、植物化学成分筛选和一些次生代谢物的定量进行了研究。
AEPM 以 60mg/kg 的剂量单次口服给药可显著降低 STZ 诱导的糖尿病大鼠的血浆葡萄糖浓度（p<0.05）。在高血糖大鼠的重复口服给药中，这种降低作用更为显著（p<0.0001）。此外，研究结果表明，该植物可显著增加糖尿病大鼠肝脏和骨骼肌比目鱼肌中的糖原含量。AEPM 除了含有多酚化合物如类黄酮、单宁、皂苷、甾醇、糖苷、萜类、醌、蒽醌和黏液质外，还显示出显著的抗氧化活性。
本研究表明，AEPM 对糖尿病大鼠具有降血糖活性，并可增加肝脏和肌肉糖原含量。
