Internal Medicine Department, Royo Villanova Hospital, Zaragoza, Spain.
Internal Medicine Department, San Agustin University Hospital, Avilés, Asturias, Spain.
PLoS One. 2021 Feb 19;16(2):e0247422. doi: 10.1371/journal.pone.0247422. eCollection 2021.
To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW).
Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality.
As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001).
Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality.
确定因 COVID-19 住院的医护人员(HCW)与非医护人员(NHCW)相比预后是否更差。
这是一项基于 SEMI-COVID-19 登记处的观察性队列研究,该登记处收集了西班牙因 COVID-19 住院的患者的社会人口统计学、临床、实验室和治疗数据。选择年龄在 20-65 岁之间的患者。使用多变量逻辑回归模型确定与死亡率相关的因素。
截至 2020 年 5 月 22 日,共纳入 4393 例患者,其中 419 例(9.5%)为 HCW。HCW 的中位(四分位间距)年龄为 52(15)岁,62.4%为女性。入院时合并症和严重影像学表现的患病率较低。HCW 对呼吸支持和入住重症监护病房的需求无差异,但发生脓毒症和院内死亡率较低(1.7%比 3.9%;p=0.024 和 0.7%比 4.8%;p<0.001)。年龄、男性和合并症与较高的院内死亡率独立相关,而 HCW 与较低的死亡率相关(OR 0.211,95%CI 0.067-0.667,p=0.008)。HCW 的 30 天生存率较高(0.968 比 0.851,p<0.001)。
COVID-19 住院 HCW 的合并症较少,预后较好。我们的结果表明,HCW 接触 COVID-19 不会导致更严重的临床症状或更高的死亡率。