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暴发性心肌炎:是新冠感染所致还是非新冠感染?是再次感染还是合并感染?

Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?

作者信息

Yeleti Ramya, Guglin Maya, Saleem Kashif, Adigopula Sasikanth V, Sinha Anjan, Upadhyay Smrity, Everett Jeffrey E, Ballut Kareem, Uppuluri Sarada, Rao Roopa A

机构信息

College of Osteopathic Medicine, Marion University, 3200 Cold Spring Rd, Indianapolis, IN 46222, USA.

Patient Author, Carmel, Indiana, IN 46032, USA.

出版信息

Future Cardiol. 2021 Nov;17(8):1307-1311. doi: 10.2217/fca-2020-0237. Epub 2021 Feb 22.

Abstract

We describe a unique case of fulminant myocarditis in a patient with presumed SARS-CoV-2 reinfection. Patient had initial infection 4 months backand had COVID-19 antibody at the time of presentation. Endomyocardial biopsy showed lymphocytic myocarditis, that is usually seen in viral myocarditis. The molecular diagnostic testing of the endomyocardial biopsy for cardiotropic viruses was positive for Parvovirus and negative for SARS-CoV-2. Authors highly suspect co-infection of SARS-CoV-2 and Parvovirus, that possibly triggered the immune cascade resulting in fulminant myocarditis. Patient was hemodynamically unstable with ventricular tachycardia and was supported on VA ECMO and Impella CP. There was impressive recovery of left ventricular function within 48 h, leading to decannulation of VA ECMO in 72 h. This unique case was written by the survivor herself.

摘要

我们描述了一例疑似感染新型冠状病毒(SARS-CoV-2)后复发的暴发性心肌炎患者的独特病例。患者4个月前初次感染,就诊时存在新冠病毒抗体。心内膜心肌活检显示淋巴细胞性心肌炎,这在病毒性心肌炎中较为常见。心内膜心肌活检针对嗜心性病毒的分子诊断检测结果显示,细小病毒呈阳性,而新型冠状病毒呈阴性。作者高度怀疑新型冠状病毒和细小病毒合并感染,这可能触发了免疫级联反应,导致暴发性心肌炎。患者血流动力学不稳定,伴有室性心动过速,接受了体外膜肺氧合(VA ECMO)和Impella CP支持治疗。左心室功能在48小时内显著恢复,72小时后VA ECMO撤机。这个独特的病例由幸存者本人撰写。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b893/7919708/61c1489568d0/figure1.jpg

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