血小板在感染检测和调控中的作用。
Role of Platelets in Detection and Regulation of Infection.
机构信息
University of Utah Molecular Medicine Program, Salt Lake City (I.P., R.A.C.).
Department of Internal Medicine, University of Utah, Salt Lake City (R.A.C.).
出版信息
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):70-78. doi: 10.1161/ATVBAHA.120.314645. Epub 2020 Oct 29.
Abstract
Platelets are classically known as essential mediators of hemostasis and thrombosis. However, in recent years, platelets have gained recognition for their inflammatory functions, which modulate the immune response during infectious diseases. Platelets contain various immunoreceptors that enable them to act as sentinels to recognize intravascular pathogens. Upon activation, platelets directly limit pathogen growth through the release of AMPs (antimicrobial proteins) and ensure pathogen clearance through activation of immune cells. However, aberrant platelet activation can lead to inflammation and thrombotic events.
摘要
血小板通常被认为是止血和血栓形成的重要介质。然而，近年来，血小板的炎症功能也得到了认可，其可以调节传染病期间的免疫反应。血小板含有各种免疫受体，使其能够作为哨兵识别血管内病原体。活化后，血小板通过释放 AMP（抗菌蛋白）直接限制病原体生长，并通过激活免疫细胞来确保病原体清除。然而，异常的血小板活化可导致炎症和血栓事件。
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