Satrústegui J, Berkowitz H, Boden B, Donlon E, McLaughlin A, Maris J, Warnell R, Chance B
Departamento de Biología Molecular, CSIC-Universidad Autónoma de Madrid, Spain.
Mech Ageing Dev. 1988 Feb;42(2):105-14. doi: 10.1016/0047-6374(88)90066-8.
Human gastrocnemius and slow twitch muscles contain phosphodiesters that may be detected in vivo by phosphorus nuclear magnetic resonance (NMR). This work represents a study of 354 spectra obtained from healthy subjects of various ages and from patients with peripheral vascular disease. The analysis of the data indicate a correlation between the concentration of phosphodiesters and age. By comparing the data obtained with healthy subjects and patients it is concluded that the increase in phosphodiesters is not due to disease, but to ageing itself. The significance of this increase is discussed.
人类腓肠肌和慢肌含有磷酸二酯，可通过磷核磁共振（NMR）在体内检测到。这项研究分析了354份光谱，这些光谱来自不同年龄段的健康受试者以及外周血管疾病患者。数据分析表明磷酸二酯浓度与年龄之间存在相关性。通过比较健康受试者和患者的数据得出结论，磷酸二酯的增加并非由疾病引起，而是由衰老本身导致。本文讨论了这种增加的意义。
