Raza Sayed Haidar Abbas, Abdelnour Sameh A, Dhshan Aya I M, Hassanin Abdallah A, Noreldin Ahmed E, Albadrani Ghadeer M, Abdel-Daim Mohamed M, Cheng Gong, Zan Linsen
College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Animal Production Department, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.
J Therm Biol. 2021 Feb;96:102859. doi: 10.1016/j.jtherbio.2021.102859. Epub 2021 Jan 20.
Thermal stress is known to have harmful effects on livestock productivity and can cause livestock enterprises considerable financial loss. These effects may be aggravated by climate change. Stress responses to nonspecific systemic actions lead to perturbation of molecular pathways in the organism. The molecular response is regulated in a dynamic and synchronized manner that assurances robustness and flexibility for the restoration of functional and structural homeostasis in stressed cells and tissues. MicroRNAs (miRNAs) are micro molecules of small non-coding RNA that control gene expression at the post-transcriptional level. Recently, various studies have discovered precise types of miRNA that regulate cellular machinery and homeostasis under various types of stress, suggesting a significant role of miRNA in thermal stress responses in animals. The miRNAs revealed in this paper could serve as promising candidates and biomarkers for heat stress and could be used as potential pharmacological targets for mitigating the consequences of thermal stress. Stress miRNA pathways may be associated with thermal stress, which offers some potential approaches to combat the negative impacts of thermal stress in livestock. The review provides new data that can assist the elucidation of the miRNA mechanisms that mediate animals' responses to thermal stress.
热应激已知会对家畜生产力产生有害影响，并可能给家畜企业造成相当大的经济损失。气候变化可能会加剧这些影响。对非特异性全身作用的应激反应会导致生物体分子途径的紊乱。分子反应以动态和同步的方式受到调节，以确保在应激细胞和组织中恢复功能和结构稳态的稳健性和灵活性。微小RNA（miRNA）是小的非编码RNA的微小分子，它们在转录后水平上控制基因表达。最近，各种研究发现了在各种应激类型下调节细胞机制和稳态的精确类型的miRNA，这表明miRNA在动物热应激反应中具有重要作用。本文中揭示的miRNA可能成为热应激的有前途的候选物和生物标志物，并可作为减轻热应激后果的潜在药理学靶点。应激miRNA途径可能与热应激有关，这为应对家畜热应激的负面影响提供了一些潜在方法。这篇综述提供了新的数据，有助于阐明介导动物对热应激反应的miRNA机制。
