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来自（L.）布里特的异欧前胡素刺激人角质形成细胞中的MAPK/ERK途径以促进皮肤伤口愈合。

Isoegomaketone from (L.) Britt Stimulates MAPK/ERK Pathway in Human Keratinocyte to Promote Skin Wound Healing.

作者信息

Kim Ye-Ram, Nam Bomi, Han Ah-Reum, Kim Jin-Baek, Jin Chang Hyun

机构信息

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeollabuk-do 56212, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2021 Feb 10;2021:6642606. doi: 10.1155/2021/6642606. eCollection 2021.

DOI:10.1155/2021/6642606
PMID:33628306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7889401/
Abstract

Skin wound healing is essential for recovery from injury, and delayed or impaired wound healing is a severe therapeutic challenge. Keratinocytes, a major component of the epidermis, play crucial roles in reepithelialization during wound healing including cell proliferation. Recent studies have shown that compounds from natural products have candidates for healing skin injury. Isoegomaketone (IK), isolated from leaves of var. (Lamiaceae), has various bioactivities. However, the effect of IK on cutaneous wound healing processes has not been studied yet. In this study, we demonstrated that IK exhibits therapeutic wound healing effects using the human keratinocyte cell line HaCaT. Notably, IK promoted cell proliferation and migration in a dose-dependent manner in vitro, and treatment with 10 M IK upregulated these processes by approximately 1.5-fold after 24 h compared with the control. IK induced the activation of the MAPK/ERK pathway and cell cycle progression to the S and G2/M phases. Thus, this study demonstrates IK as a potential candidate to upregulate wound healing that may provide therapeutic benefits to patients with delayed wound healing.

摘要

皮肤伤口愈合对于损伤恢复至关重要，而伤口愈合延迟或受损是一项严峻的治疗挑战。角质形成细胞是表皮的主要成分，在伤口愈合过程中的再上皮化包括细胞增殖中发挥关键作用。最近的研究表明，天然产物中的化合物有望用于治疗皮肤损伤。从糙苏属植物（唇形科）叶片中分离出的异欧前胡素（IK）具有多种生物活性。然而，IK对皮肤伤口愈合过程的影响尚未得到研究。在本研究中，我们使用人角质形成细胞系HaCaT证明了IK具有治疗伤口愈合的作用。值得注意的是，IK在体外以剂量依赖性方式促进细胞增殖和迁移，与对照组相比，用10 μM IK处理24小时后，这些过程上调了约1.5倍。IK诱导MAPK/ERK途径的激活以及细胞周期进展至S期和G2/M期。因此，本研究证明IK是上调伤口愈合的潜在候选物，可能为伤口愈合延迟的患者提供治疗益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/25be79a5c61c/ECAM2021-6642606.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/da769822650d/ECAM2021-6642606.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/e1e60164d062/ECAM2021-6642606.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/9c3cec722a36/ECAM2021-6642606.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/25be79a5c61c/ECAM2021-6642606.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/da769822650d/ECAM2021-6642606.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/e1e60164d062/ECAM2021-6642606.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/9c3cec722a36/ECAM2021-6642606.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09f1/7889401/25be79a5c61c/ECAM2021-6642606.004.jpg

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