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蔷薇科植物溶剂提取物对瑞士白化小鼠止泻活性的评估

Evaluation of Antidiarrheal Activity of Solvent Fractions of (Rosaceae) in Swiss Albino Mice.

作者信息

Kifle Zemene Demelash, Kidanu Birhanu Berihun, Tadesse Tesfaye Yimer, Belachew Teshome Fentik, Atnafie Seyfe Asrade

机构信息

University of Gondar, College of Medicine and Health Sciences, School of Pharmacy, Department of Pharmacology, Gondar, Ethiopia.

University of Gondar, College of Veterinary Medicine and Animal Sciences, Department of Veterinary Pharmacy, Gondar, Ethiopia.

出版信息

Evid Based Complement Alternat Med. 2021 Feb 13;2021:8828331. doi: 10.1155/2021/8828331. eCollection 2021.

Abstract

BACKGROUND

Ethiopia has several medicinal plants that have been used for their antidiarrheal activity. is the most commonly used medicinal plant for the management of diarrhea in Ethiopia. Thus, this study's aim is to investigate the antidiarrheal effect of solvent fractions of .

METHODS

Antidiarrheal activity of extract fractions obtained from different solvents was evaluated by using small intestine transit, enteropooling, and castor oil-induced diarrhea animal models. In all animal models, the solvent fractions treated groups were treated with three different doses (100 mg/kg, 200 mg/kg, and 400 mg/kg) of the solvent fractions, while the negative control group was treated with a vehicle (distilled water), and positive control group was treated with loperamide.

RESULTS

The acute toxicity test revealed that the LD of is > 2000 mg/kg. In castor oil-induced, the solvent fractions of (at 200 mg/kg and 400 mg/kg) significantly ( < 0.05-0.001) prolonged the stool frequency, reduced the weight of feces, and delayed diarrheal onset time as compared with the negative control group. The fractions produced a significant ( < 0.05) antimotility effect at the doses of 200 mg/kg and 400 mg/kg as compared to the negative control. All solvent fractions at the middle and higher doses showed a statistically significant dose-dependent reduction in the volume of intestinal contents and weight of the feces. However, the solvent fractions of at a dose of 100 mg/kg failed to produce a statistically significant activity in all parameters (number of wet feces, the onset of diarrhea, and number of total feces) when compared with the negative control group.

CONCLUSION

The extract fractions obtained from different solvents have shown significant antidiarrheal activity. Thus, this finding supports the claimed traditional use of leaves for the treatment of diarrhea.

摘要

背景

埃塞俄比亚有几种药用植物因其抗腹泻活性而被使用。[植物名称]是埃塞俄比亚治疗腹泻最常用的药用植物。因此,本研究的目的是调查[植物名称]溶剂提取物的抗腹泻作用。

方法

通过小肠推进、肠积液和蓖麻油诱导腹泻动物模型评估不同溶剂获得的提取物的抗腹泻活性。在所有动物模型中,溶剂提取物处理组用三种不同剂量(100mg/kg、200mg/kg和400mg/kg)的溶剂提取物处理,阴性对照组用赋形剂(蒸馏水)处理,阳性对照组用洛哌丁胺处理。

结果

急性毒性试验表明,[植物名称]的半数致死量>2000mg/kg。在蓖麻油诱导的腹泻模型中,[植物名称]的溶剂提取物(200mg/kg和400mg/kg)与阴性对照组相比,显著(P<0.05 - 0.001)延长了排便频率,减轻了粪便重量,并延迟了腹泻发作时间。与阴性对照组相比,200mg/kg和400mg/kg剂量的提取物产生了显著(P<0.05)的抗蠕动作用。所有中高剂量的溶剂提取物在肠道内容物体积和粪便重量方面均显示出统计学上显著的剂量依赖性降低。然而,与阴性对照组相比,100mg/kg剂量的[植物名称]溶剂提取物在所有参数(湿粪数量、腹泻发作和总粪数量)上均未产生统计学上显著的活性。

结论

从不同溶剂中获得的提取物显示出显著的抗腹泻活性。因此,这一发现支持了[植物名称]叶治疗腹泻的传统用法。

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