Lotfali Ensieh, Mardani Masoud, Abolghasemi Sara, Darvishnia David, Rabiei Mohammad Mahdi, Ghasemi Reza, Fattahi Azam
Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medial Sciences, Tehran, Iran.
Curr Med Mycol. 2020 Jun;6(2):58-62. doi: 10.18502/CMM.6.2.2695.
Oropharyngeal candidiasis (OPC) is a fungal infection of the oral cavity caused by the members of complex. Although , as a part of the complex, is considered to be mostly responsible for the development of vulvovaginal candidiasis, it may be associated with a wider clinical spectrum.
This report described two cases diagnosed with oral candidiasis during the receipt of treatment for malignancies. Conventional and molecular tests were performed on the samples collected from the patients' oral cavities. The test results revealed as the causative agent of oral candidiasis. Furthermore, in vitro antifungal susceptibility test indicated the full susceptibility of all isolates to caspofungin. However, the data were also suggestive of the resistance against fluconazole and amphotericin B. Caspofungin was used as the main antifungal agent for the treatment of oral candidiasis, resulting in the improvement of thrush in patients. The resistance of to fluconazole and amphotericin B suggests the necessity of performing in vitro susceptibility testing on the isolates for the selection of appropriate antifungal agents.
As the findings indicated, the achievement of knowledge regarding as an emerging non-albicans Candida species and its antifungal susceptibility profile is crucial to select antifungal prophylaxis and empirical therapy for oral candidiasis in cancer patients undergoing chemotherapy.
non.
口腔念珠菌病（OPC）是由念珠菌属复合体成员引起的口腔真菌感染。虽然作为该复合体的一部分，白色念珠菌被认为是外阴阴道念珠菌病发病的主要原因，但它可能与更广泛的临床谱相关。
本报告描述了两例在接受恶性肿瘤治疗期间被诊断为口腔念珠菌病的病例。对从患者口腔采集的样本进行了常规和分子检测。检测结果显示光滑念珠菌是口腔念珠菌病的病原体。此外，体外抗真菌药敏试验表明所有光滑念珠菌分离株对卡泊芬净完全敏感。然而，数据也提示对氟康唑和两性霉素B耐药。卡泊芬净被用作治疗口腔念珠菌病的主要抗真菌药物，使患者的鹅口疮得到改善。光滑念珠菌对氟康唑和两性霉素B的耐药性表明有必要对分离株进行体外药敏试验以选择合适的抗真菌药物。
如研究结果所示了解光滑念珠菌作为一种新兴的非白色念珠菌及其抗真菌药敏谱对于为接受化疗的癌症患者选择口腔念珠菌病的抗真菌预防和经验性治疗至关重要。
无。
