Hayase Kazuma, Kainuma Atsushi, Akiyama Koichi, Kinoshita Mao, Shibasaki Masayuki, Sawa Teiji
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Front Physiol. 2021 Feb 9;12:627088. doi: 10.3389/fphys.2021.627088. eCollection 2021.
The Poincaré plot obtained from electroencephalography (EEG) has been used to evaluate the depth of anesthesia. A standalone EEG Analyzer application was developed; raw EEG signals obtained from a bispectral index (BIS) monitor were analyzed using an on-line monitoring system. Correlations between Poincaré plot parameters and other measurements associated with anesthesia depth were evaluated during emergence from inhalational general anesthesia. Of the participants, 20 were adults anesthetized with sevoflurane (adult ), 20 were adults anesthetized with desflurane (adult ), and 20 were pediatric patients anesthetized with sevoflurane (ped ). EEG signals were preprocessed through six bandpass digital filters (f0: 0.5-47 Hz, f1: 0.5-8 Hz, f2: 8-13 Hz, f3: 13-20 Hz, f4: 20-30 Hz, and f5: 30-47 Hz). The Poincaré plot-area ratio (PP = PP /PP , fx = f1∼f5) was analyzed at five frequency ranges. Regardless of the inhalational anesthetic used, there were strong linear correlations between the logarithm of PP at f5 and BIS ( = 0.67, 0.79, and 0.71, in the adult , adult , and ped groups, respectively). As an additional observation, a part of EMG activity at the gamma range of 30-47 Hz probably influenced the calculations of BIS and PP with a non-negligible level. The logarithm of PP in the gamma band was most sensitive to state changes during the emergence process and could provide a new non-proprietary parameter that correlates with changes in BIS during measurement of anesthesia depth.
从脑电图（EEG）获得的庞加莱图已被用于评估麻醉深度。开发了一个独立的EEG分析仪应用程序；使用在线监测系统分析从双谱指数（BIS）监测仪获得的原始EEG信号。在吸入全身麻醉苏醒过程中，评估庞加莱图参数与其他麻醉深度相关测量值之间的相关性。参与者中，20名是接受七氟醚麻醉的成年人（成年组），20名是接受地氟醚麻醉的成年人（成年组），20名是接受七氟醚麻醉的儿科患者（儿科组）。EEG信号通过六个带通数字滤波器进行预处理（f0：0.5 - 47Hz，f1：0.5 - 8Hz，f2：8 - 13Hz，f3：13 - 20Hz，f4：20 - 30Hz，f5：30 - 47Hz）。在五个频率范围内分析庞加莱图面积比（PP = PP /PP ，fx = f1∼f5）。无论使用何种吸入麻醉剂，在f5处PP 的对数与BIS之间均存在强线性相关性（成年组、成年组和儿科组的 分别为0.67、0.79和0.71）。作为一项额外观察，30 - 47Hz伽马范围内的部分肌电图活动可能对BIS和PP 的计算产生不可忽略程度的影响。伽马波段中PP的对数在苏醒过程中对状态变化最为敏感，并且可以提供一个与麻醉深度测量期间BIS变化相关的新的非专利参数。
