Adrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, São Paulo, Brazil.
Corpometria Institute, Brasilia, Distrito Federal, Brazil.
BMJ Case Rep. 2021 Feb 26;14(2):e241572. doi: 10.1136/bcr-2021-241572.
A severe case of COVID-19 was observed in an otherwise healthy 28-year-old man who had taken oxandrolone 40 mg/day as an anabolic steroid. The patient had been taking oxandrolone for enhanced bodybuilding 30 days prior to presenting to an outpatient clinic with COVID-19 symptoms. The patient reported that his symptoms have rapidly worsened over the course of 4 days prior to presenting at the clinic. As part of an experimental antiandrogen treatment for hyperandrogenic men suffering from COVID-19, he was administered a single 600 mg dose of the novel antiandrogen proxalutamide. Twenty-four hours after administration of this dose, marked improvement of symptoms and markers of disease severity were observed. To our knowledge, this is the first case that potentially links anabolic steroid use to COVID-19 disease severity.
观察到一例严重的 COVID-19 病例，患者为一名原本健康的 28 岁男性，每日服用氧雄龙 40mg，作为一种合成代谢类固醇。该患者在出现 COVID-19 症状前 30 天开始服用氧雄龙进行增肌。该患者报告称，在前往诊所就诊前的 4 天内，他的症状迅速恶化。作为一种针对 COVID-19 高雄性激素男性的新型抗雄激素治疗的实验性治疗，他接受了单次 600mg 的新型抗雄激素普罗芦卡胺治疗。给药 24 小时后，观察到症状和疾病严重程度的标志物明显改善。据我们所知，这是首例可能将合成代谢类固醇使用与 COVID-19 疾病严重程度联系起来的病例。
