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Genome-wide identification of key regulatory lncRNAs in esophageal cancer metastasis.

作者信息

Xu Wen Wen, Zheng Can-Can, Zuo Qian, Li Jun-Qi, Hong Pan, Qin Yan-Ru, Guan Xin-Yuan, He Qing-Yu, Liao Hua-Xin, Li Bin

机构信息

MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China.

MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China.

出版信息

Signal Transduct Target Ther. 2021 Feb 27;6(1):88. doi: 10.1038/s41392-021-00476-9.

DOI:10.1038/s41392-021-00476-9
PMID:33637684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910292/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e6/7910292/c348b3252e84/41392_2021_476_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e6/7910292/c348b3252e84/41392_2021_476_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0e6/7910292/c348b3252e84/41392_2021_476_Fig1_HTML.jpg

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Genome-wide identification of key regulatory lncRNAs in esophageal cancer metastasis.食管癌转移中关键调控性长链非编码RNA的全基因组鉴定
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2
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RNA sequencing of exosomes revealed differentially expressed long noncoding RNAs in early-stage esophageal squamous cell carcinoma and benign esophagitis.外泌体的 RNA 测序显示，早期食管鳞状细胞癌和良性食管炎中长链非编码 RNA 的表达存在差异。
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Circular RNA circ-PRKCI functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-3680-3p in esophageal squamous cell carcinoma.环状RNA circ-PRKCI作为一种竞争性内源性RNA，通过吸附食管鳞状细胞癌中的miR-3680-3p来调节AKT3的表达。
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本文引用的文献

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Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance.miR-515-3p 及其靶基因波形蛋白和 MMP3 在食管癌转移中的关键调控机制鉴定：功能和临床意义。
Signal Transduct Target Ther. 2020 Nov 27;5(1):271. doi: 10.1038/s41392-020-00275-8.
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Emerging Biological Principles of Metastasis.转移的新兴生物学原理
Cell. 2017 Feb 9;168(4):670-691. doi: 10.1016/j.cell.2016.11.037.
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On the origin of cancer metastasis.论癌症转移的起源
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
KCTD4与CLIC1相互作用，破坏钙稳态并促进食管癌转移。
Acta Pharm Sin B. 2023 Oct;13(10):4217-4233. doi: 10.1016/j.apsb.2023.07.013. Epub 2023 Jul 17.
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Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance.由KAT8和HDAC11调控的HSP90赖氨酸丁酰化赋予化学抗性。
Cell Discov. 2023 Jul 18;9(1):74. doi: 10.1038/s41421-023-00570-y.
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Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.赖氨酸 2-羟基异丁酰化 NAT10 通过 ac4C 依赖性方式促进癌症转移。
Cell Res. 2023 May;33(5):355-371. doi: 10.1038/s41422-023-00793-4. Epub 2023 Mar 8.
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N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.N4-乙酰胞苷修饰长链非编码 RNA CTC-490G23.2 通过与 PTBP1 相互作用促进癌症转移，从而增加 CD44 可变剪接。
Oncogene. 2023 Mar;42(14):1101-1116. doi: 10.1038/s41388-023-02628-3. Epub 2023 Feb 16.
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Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression.阻断 NMT1 的酶活性抑制 VILIP3 蛋白的 N-豆蔻酰化，从而抑制肝癌进展。
Signal Transduct Target Ther. 2023 Jan 9;8(1):14. doi: 10.1038/s41392-022-01248-9.
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KTN1-AS1, a SOX2-mediated lncRNA, activates epithelial-mesenchymal transition process in esophageal squamous cell carcinoma.KTN1-AS1，一种 SOX2 介导的长非编码 RNA，在食管鳞状细胞癌中激活上皮-间充质转化过程。
Sci Rep. 2022 Nov 23;12(1):20186. doi: 10.1038/s41598-022-24743-z.
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Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis.通过靶向 RanBP3 的 NU2058 阻断核 β-连环蛋白信号转导诱导细胞衰老抑制结直肠肿瘤发生。
Adv Sci (Weinh). 2022 Dec;9(34):e2202528. doi: 10.1002/advs.202202528. Epub 2022 Oct 21.
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Cell. 2006 Nov 17;127(4):679-95. doi: 10.1016/j.cell.2006.11.001.