College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 164, Lanxi Road, Putuo District, Shanghai, 200062, China.
Adv Healthc Mater. 2021 May;10(10):e2002024. doi: 10.1002/adhm.202002024. Epub 2021 Feb 28.
Radiotherapy (RT) is a popular clinical therapy method for extending cancer patient survival, but is hampered by severe side effects and the weak therapy effect. Herein, responsive degradable selenium (Se) theranostic agents (Se@SiO @Bi nanocomposites (NCs)) are fabricated, which combine computed tomography (CT) imaging and simultaneously enhance the therapeutic effects of photothermal therapy (PTT) and RT, while reducing the side effects of radiation. The Se@SiO @Bi theranostic agents can accumulate at the tumor site, and responsively decompose to releease Se, avoiding systemic toxicity by the element. Se enhances the effect of PTT/RT, simultaneously reducing the side effects of RT. The Se@SiO @Bi NCs as CT agents also exhibit significantly enhanced contrast imaging performance due to the high atomic number of Bi. More importantly, the Se@SiO @Bi NCs can be rapidly excreted without long-term toxicity, owing to responsive degradation into ultrasmall particles (<5 nm) at the tumor site. In vitro and in vivo results show that the Se@SiO @Bi NCs can remarkably inhibit tumor cells, without causing appreciable toxicity during the treatment. This study opens a new perspective in rationally designing responsive degradable theranostic agents for future tumor therapy with enhanced therapeutic efficacy and lesser side effects.
放射治疗（RT）是一种延长癌症患者生存期的常用临床治疗方法，但受到严重副作用和弱治疗效果的限制。在此，制备了响应性可降解硒（Se）治疗剂（Se@SiO@Bi 纳米复合材料（NCs）），它结合了计算机断层扫描（CT）成像，同时增强了光热治疗（PTT）和 RT 的治疗效果，同时降低了辐射的副作用。Se@SiO@Bi 治疗剂可以在肿瘤部位积聚，并响应性地分解以释放 Se，避免了元素的全身毒性。Se 增强了 PTT/RT 的效果，同时降低了 RT 的副作用。作为 CT 造影剂的 Se@SiO@Bi NCs 也由于 Bi 的高原子序数而表现出显著增强的对比成像性能。更重要的是，由于在肿瘤部位响应性降解成小于 5nm 的超小颗粒，Se@SiO@Bi NCs 可以迅速排出体外，没有长期毒性。体外和体内结果表明，Se@SiO@Bi NCs 可以显著抑制肿瘤细胞，在治疗过程中没有引起明显的毒性。这项研究为未来具有增强治疗效果和更少副作用的肿瘤治疗合理设计响应性可降解治疗剂开辟了新的视角。
