Wang Zheng, He Hong-Juan, Li Xiu-Min, Miao Ming-San
Henan University of Chinese Medicine Zhengzhou 450046,China.
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(4):757-761. doi: 10.19540/j.cnki.cjcmm.20200916.602.
This article aims to provide a good experimental method for the study of drug treatment of ulcerative colitis. According to the characteristics of ulcerative colitis's clinical symptoms, common ulcerative colitis animal models were analyzed. Based on the characteristics of clinical symptoms of traditional Chinese medicine and Western medicine for ulcerative colitis disease, the existing commonly used animal models of ulcerative colitis were analyzed to summarize the current matching degree, advantages and disadvantages of the exi-sting animal models of ulcerative colitis and clinical symptoms. At present, studies on ulcerative colitis mainly adopt four types of induction modeling methods, such as immunization, chemical stimulation, compound method and gene model. There are many reported methods of colitis modeling, but no model can reflect the characteristics of clinical symptoms of ulcerative colitis treated with Western or Chinese medicine. This article summarizes the characteristics, clinically relevant symptoms and applicable scope of immunization, chemical stimulation, compound method, and gene model, so as to provide a reliable animal model for subsequent studies of prevention and treatment of colitis.
本文旨在为溃疡性结肠炎的药物治疗研究提供一种良好的实验方法。根据溃疡性结肠炎临床症状的特点，对常见的溃疡性结肠炎动物模型进行了分析。基于中西医对溃疡性结肠炎疾病临床症状的特点，对现有的常用溃疡性结肠炎动物模型进行分析，总结目前溃疡性结肠炎动物模型与临床症状的匹配程度、优缺点。目前，溃疡性结肠炎的研究主要采用免疫、化学刺激、复合方法和基因模型等四种诱导建模方法。有许多关于结肠炎建模的报道方法，但没有一种模型能够反映中西医治疗溃疡性结肠炎临床症状的特点。本文总结了免疫、化学刺激、复合方法和基因模型的特点、临床相关症状及适用范围，以便为后续结肠炎防治研究提供可靠的动物模型。
