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冠状病毒及其在全球范围内的可怕影响:制药行业站在抗疫前线。

Coronavirus and its terrifying inning around the globe: The pharmaceutical cares at the main frontline.

机构信息

Department of Pharmacy, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan.

Department of Pharmacy, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan.

出版信息

Chemosphere. 2021 Jul;275:129968. doi: 10.1016/j.chemosphere.2021.129968. Epub 2021 Feb 16.

Abstract

A novel coronavirus (2019-nCoV) is an acute life-threatening disease, emerged in China, which imposed a potentially immense toll in terms of public health emergency due to high infection rate and has a devastating economic impact that attracts the world's attention. After that, on January 30, 2020, it was officially declared as a global pandemic by World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) recognized it as a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and the disease named Coronavirus Disease-19 (COVID-19). Several studies have been ameliorated the active role of COVID-19 transmission, etiology, pathogenicity, and mortality rate as serious impact on human life. The symptoms of this disease may include fever, fatigue, cough and some peoples are severely prone to gastrointestinal infection. The elderly and seriously affected peoples are likely concerned with serious outcomes. In this review, we mainly aimed to provide a benchmark summary of the silent characteristics and findings of some candidates for antiviral drugs and immunotherapies such as plasma therapy, cytokine therapy, antibodies, intravenous immunoglobulin, and pharmaceutical health concerns that are related to this disease.

摘要

一种新型冠状病毒(2019-nCoV)是一种急性致命疾病,起源于中国,由于高感染率,对公共卫生紧急情况造成了潜在的巨大威胁,并产生了破坏性的经济影响,引起了全世界的关注。此后,2020 年 1 月 30 日,世界卫生组织(WHO)正式宣布其为全球大流行。国际病毒分类委员会(ICTV)将其认定为严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2),并将该病命名为冠状病毒病 19(COVID-19)。多项研究表明,COVID-19 的传播、病因、发病机制和死亡率对人类生命有严重影响。这种疾病的症状可能包括发热、乏力、咳嗽,有些人还容易出现胃肠道感染。老年人和受严重影响的人可能会出现严重的后果。在这篇综述中,我们主要旨在提供一个关于抗病毒药物和免疫疗法的候选药物的潜在特征和研究结果的基准总结,如血浆疗法、细胞因子疗法、抗体、静脉注射免疫球蛋白,以及与这种疾病相关的药物健康问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b8/7884917/d10c377e4960/gr1_lrg.jpg

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