Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Arch Physiol Biochem. 2023 Dec;129(4):998-1006. doi: 10.1080/13813455.2021.1890131. Epub 2021 Mar 3.
The novel 2019 coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly transmissible and pathogenic coronavirus. Because of the novelty of the COVID-19 pandemic, few data are available on the impact of the SARS-CoV-2 on the different endocrine glands. Previous studies of severe acute respiratory syndrome (SARS) have shown a harmful effect on endocrine function. Notably, the angiotensin-converting enzyme-2 receptor, which is the entry route of coronaviruses to the host cell, is widely expressed in the endocrine organs including testis, endocrine pancreas, thyroid, and adrenal, and pituitary glands. Clinical and biochemical manifestations have been recorded in COVID-19 patients resulting in changes in endocrine activities, which were also recorded during the SARS outbreak in 2003. This review aims to explore the impact of SARS-CoV-2 infection on the function of endocrine glands, based on the latest research in the field.
新型冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的，它是一种高度传染性和致病性的冠状病毒。由于 COVID-19 大流行的新颖性，关于 SARS-CoV-2 对不同内分泌腺的影响的数据很少。先前对严重急性呼吸系统综合征（SARS）的研究表明，它对内分泌功能有不良影响。值得注意的是，血管紧张素转换酶 2 受体是冠状病毒进入宿主细胞的途径，它在包括睾丸、内分泌胰腺、甲状腺和肾上腺以及垂体在内的内分泌器官中广泛表达。在 COVID-19 患者中已经记录到了导致内分泌活动变化的临床和生化表现，这在 2003 年 SARS 爆发期间也有记录。本综述旨在根据该领域的最新研究，探讨 SARS-CoV-2 感染对内分泌腺功能的影响。
