Syler Lee B, Gooden Casey, Riddle Nicole
Pathology, University of South Florida, Tampa, USA.
Pathology, Ruffolo, Hooper & Associates, Tampa, USA.
Cureus. 2021 Jan 25;13(1):e12898. doi: 10.7759/cureus.12898.
The coexistence of two separate malignancies in a patient is a rare occurrence. Even more infrequent is the coexistence of a hematologic malignancy and a solid tumor. However, the relationship between renal cell carcinoma (RCC) and plasma cell myeloma (PCM) has been reported in previous studies. These studies described synchronous cases of RCC and PCM and demonstrated that this situation occurs more frequently than expected by probability calculations. We present, what we believe to be, the first reported case of RCC directly and physically involved by PCM and, we review the literature on the association between these malignancies and explore possible mechanisms for their higher than expected association. In describing this case, emphasis is made to describe unique histologic findings that could further support a more direct and intimate association between these tumors.
一名患者同时存在两种独立的恶性肿瘤是一种罕见的情况。血液系统恶性肿瘤与实体瘤同时存在的情况更为罕见。然而，先前的研究已经报道了肾细胞癌（RCC）与浆细胞骨髓瘤（PCM）之间的关系。这些研究描述了RCC和PCM的同步病例，并表明这种情况的发生频率高于概率计算的预期。我们呈现了我们认为是首例PCM直接累及RCC的报道病例，并回顾了关于这些恶性肿瘤关联的文献，探讨了它们关联高于预期的可能机制。在描述该病例时，着重描述了独特的组织学发现，这些发现可能进一步支持这些肿瘤之间更直接和密切的关联。
