痢疾志贺氏菌培养滤液中的毒素，可引起中国仓鼠卵巢细胞形态变化，且与神经毒素不同。
Toxin from the culture filtrate of Shigella dysenteriae that causes morphological changes in Chinese hamster ovary cells and is distinct from the neurotoxin.
作者信息
Takeda Y, Okamoto K, Miwatani T
出版信息
Infect Immun. 1977 Nov;18(2):546-8. doi: 10.1128/iai.18.2.546-548.1977.
Abstract
A toxin that causes morphological changes in Chinese hamster ovary cells was isolated from a culture filtrate of Shigella dysenteriae 1. It was partially purified by successive column chromatography on diethylaminoethyl-cellulose, Bio-Gel A-5m, and hydroxylapatite. The toxin was separated from neurotoxin by diethylaminoethyl-cellulose column chromatography and was not lethal for mice.
摘要
从痢疾志贺氏菌1型的培养滤液中分离出一种可引起中国仓鼠卵巢细胞形态变化的毒素。通过在二乙氨基乙基纤维素、生物凝胶A-5m和羟基磷灰石上连续柱层析对其进行部分纯化。该毒素通过二乙氨基乙基纤维素柱层析与神经毒素分离，对小鼠无致死性。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The neurotoxin of Shigella shigae. I. Production, purification and properties of the toxin.痢疾志贺氏菌的神经毒素。I. 毒素的产生、纯化及性质
Br J Exp Pathol. 1953 Apr;34(2):202-16.
3
The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I.志贺氏菌腹泻的发病机制。一、痢疾志贺氏菌I型产生肠毒素。
J Clin Invest. 1972 May;51(5):1212-8. doi: 10.1172/JCI106915.
4
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli.环磷酸腺苷与中国仓鼠卵巢细胞形态改变：一种用于检测霍乱弧菌和大肠杆菌肠毒素的快速、灵敏的体外测定法。
Infect Immun. 1974 Aug;10(2):320-7. doi: 10.1128/iai.10.2.320-327.1974.
5
Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.霍乱毒素处理后肠黏膜中3':5'-环磷酸腺苷浓度升高。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):851-6. doi: 10.1073/pnas.67.2.851.
6
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.霍乱肠毒素和前列腺素对肠黏膜腺苷酸环化酶的刺激作用。
J Clin Invest. 1971 Jun;50(6):1218-30. doi: 10.1172/JCI106599.
7
Field M: Intestinal secretion: effect of cyclic AMP and its role in cholera.菲尔德·M：肠道分泌：环磷酸腺苷的作用及其在霍乱中的角色。
N Engl J Med. 1971 May 20;284(20):1137-44. doi: 10.1056/NEJM197105202842008.
8
Stimulation of intestinal adenyl cyclase by cholera toxin.霍乱毒素对肠道腺苷酸环化酶的刺激作用。
Nature. 1971 Jan 22;229(5282):266-9. doi: 10.1038/229266a0.
9
Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone.二丁酰腺苷环3':5'-单磷酸酯和睾酮对中国仓鼠细胞的形态学转化
Proc Natl Acad Sci U S A. 1971 Feb;68(2):358-61. doi: 10.1073/pnas.68.2.358.
10
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J Infect Dis. 1975 May;131(5):559-66. doi: 10.1093/infdis/131.5.559.
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