Bioconjug Chem. 2021 Mar 17;32(3):448-465. doi: 10.1021/acs.bioconjchem.1c00014. Epub 2021 Mar 3.
Peptides are signaling epitopes that control many vital biological events. Increased specificity, synthetic feasibility with concomitant lack of toxicity, and immunogenicity make this emerging class of biomolecules suitable for different applications including therapeutics, diagnostics, and biomedical engineering. Further, chitosan, a naturally occurring linear polymer composed of d-glucosamine and -acetyl-d-glucosamine units, possesses anti-microbial, muco-adhesive, and hemostatic properties along with excellent biocompatibility. As a result, chitosan finds application in drug/gene delivery, tissue engineering, and bioimaging. Despite these applications, chitosan demonstrates limited cell adhesion and lacks biosignaling. Therefore, peptide-chitosan hybrids have emerged as a new class of biomaterial with improved biosignaling properties and cell adhesion properties. As a result, recent studies encompass increased application of peptide-chitosan hybrids as composites or conjugates in drug delivery, cell therapy, and tissue engineering and as anti-microbial material. This review discusses the recent investigations involving chitosan-peptide materials and uncovers various aspects of these interesting hybrid materials for biomedical applications.
肽是控制许多重要生物事件的信号表位。其具有更高的特异性、合成可行性以及缺乏毒性和免疫原性，这使得这一新兴的生物分子类别适合于不同的应用，包括治疗学、诊断学和生物医学工程。此外，壳聚糖是一种由 d-葡萄糖胺和 -乙酰-d-葡萄糖胺单元组成的天然存在的线性聚合物，具有抗微生物、黏膜黏附性和止血特性以及出色的生物相容性。因此，壳聚糖在药物/基因递送、组织工程和生物成像中有应用。尽管有这些应用，壳聚糖表现出有限的细胞黏附性并且缺乏生物信号转导。因此，肽-壳聚糖杂化物已成为一类具有改善的生物信号转导特性和细胞黏附特性的新型生物材料。因此，最近的研究增加了肽-壳聚糖杂化物在药物递送、细胞治疗和组织工程以及抗菌材料中的复合材料或缀合物的应用。本文综述了涉及壳聚糖-肽材料的最新研究，并揭示了这些有趣的杂化材料在生物医学应用中的各个方面。
