Kharitonova Maya, Vankov Peter, Abdrakhmanov Airat, Mamaeva Elena, Yakovleva Galina, Ilinskaya Olga
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia.
Department of Pediatric Dentistry, Kazan State Medical University, Butlerova Str. 49, Kazan 420012, Russia.
AIMS Microbiol. 2021 Jan 27;7(1):59-74. doi: 10.3934/microbiol.2021005. eCollection 2021.
Host susceptibility and environmental factors are important for the development of gingivitis and periodontitis, but bacterial biofilms attached to the teeth and gingival tissues play a crucial role. We have analyzed and compared the subgingival microbial communities between subjects with dental plaque biofilm-induced generalized chronic gingivitis (CG), localized initial (Stage I) periodontitis (IP) and healthy controls (HC) of young people aged 18-19 years permanently residing in the city of Kazan (Tatarstan, Russia). The results showed that the α-diversity in groups with CG and IP was higher than in the healthy group. In a course of periodontal disease, a decrease in the relative abundance of dominates genera Rothia and Streptococcus was observed along with increase of class TM7-3 (Candidatus Saccharibacteria phylum) representatives. Also, the increase of red complex representatives Porphyromonadeceae, Treponema and Tannerella was detected together with statistically significant increase of Filifactor, Parvimonas, Peptostreptococcaceae, Veillonellaceae, Tissierelaceae and Mogibacteriaceae. Analysis of our data suggests that transition from HC to IP may be accompanied by a decrease in microbial diversity and a reduction in the abundance of family Rs-045 (Candidatus Saccharibacteria phylum), Desulfovibrionaceae Corynebacterium, Campylobacter and Selenomonas in young adults Kazan Tatars.
宿主易感性和环境因素对牙龈炎和牙周炎的发展很重要，但附着在牙齿和牙龈组织上的细菌生物膜起着关键作用。我们分析并比较了长期居住在俄罗斯鞑靼斯坦共和国喀山市的18 - 19岁年轻人中，患有牙菌斑生物膜诱导的广泛性慢性牙龈炎（CG）、局限性初期（I期）牙周炎（IP）的受试者与健康对照（HC）之间的龈下微生物群落。结果显示，CG组和IP组的α多样性高于健康组。在牙周疾病过程中，观察到优势菌属罗氏菌属和链球菌属的相对丰度下降，同时TM7 - 3纲（候选糖菌门）代表菌增加。此外，检测到红色复合体代表菌卟啉单胞菌科、密螺旋体属和坦纳菌属增加，同时丝状杆菌属、小单胞菌属、消化链球菌科、韦荣球菌科、蒂氏菌科和栖粪杆菌属的丰度有统计学意义的增加。对我们数据的分析表明，从HC到IP的转变可能伴随着喀山鞑靼族年轻人微生物多样性的降低以及Rs - 045科（候选糖菌门）、脱硫弧菌科、棒状杆菌属、弯曲杆菌属和栖硫单胞菌属丰度的减少。
