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肌腱病的最新进展

Recent advances in tendinopathy.

作者信息

Challoumas Dimitris, Biddle Mairiosa, Millar Neal L

机构信息

Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, The University of Glasgow, Glasgow, UK.

Department of Orthopaedic Surgery, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.

出版信息

Fac Rev. 2020 Nov 19;9:16. doi: 10.12703/b/9-16. eCollection 2020.

DOI:10.12703/b/9-16
PMID:33659948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7886058/
Abstract

Tendinopathy refers to the clinical diagnosis of activity-related pain resulting in a decline in tendon function. In the last few years, much has been published concerning the basic science and clinical investigation of tendinopathy and debates and discussions to new questions and points of view started many years ago. This advances review will discuss the current thinking on the basic science and clinical management of tendinopathy and in particular new findings in the tendon repair space that are relevant to the pathophysiology of tendinopathy. We will further discuss potential novel therapies on the horizon in human tendon disease.

摘要

肌腱病是指与活动相关的疼痛的临床诊断,这种疼痛会导致肌腱功能下降。在过去几年中,已经发表了许多关于肌腱病基础科学和临床研究的文章,并且多年前就开始了关于新问题和新观点的辩论与讨论。这篇进展综述将讨论目前关于肌腱病基础科学和临床管理的观点,特别是与肌腱病病理生理学相关的肌腱修复领域的新发现。我们还将进一步讨论人类肌腱疾病中即将出现的潜在新疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c7/7886058/32dd7543e116/facrev-09-16-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c7/7886058/32dd7543e116/facrev-09-16-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c7/7886058/32dd7543e116/facrev-09-16-g001.jpg

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Effectiveness of isometric exercise in the management of tendinopathy: a systematic review and meta-analysis of randomised trials.等长运动在肌腱病管理中的有效性:一项随机试验的系统评价和荟萃分析
BMJ Open Sport Exerc Med. 2020 Aug 4;6(1):e000760. doi: 10.1136/bmjsem-2020-000760. eCollection 2020.
2
Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy.基因治疗、非编码 RNA 和基于外泌体的治疗在腱病治疗中的研究进展。
Ann N Y Acad Sci. 2021 Apr;1490(1):3-12. doi: 10.1111/nyas.14382. Epub 2020 Jun 5.
3
ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons.
肌腱-骨愈合的挑战:强调炎症调节机制和治疗。
Front Endocrinol (Lausanne). 2024 Nov 6;15:1485876. doi: 10.3389/fendo.2024.1485876. eCollection 2024.
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Advancements in Therapeutic Approaches for Degenerative Tendinopathy: Evaluating Efficacy and Challenges.退行性腱病治疗方法的进展:评估疗效和挑战。
Int J Mol Sci. 2024 Nov 4;25(21):11846. doi: 10.3390/ijms252111846.
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Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies.新型维生素 C、胶原蛋白肽、白藜芦醇和虾青素混合物在肌腱细胞中的抗炎和抗氧化特性:未来在腱病中应用的分子基础。
Mediators Inflamm. 2024 Jul 30;2024:5273198. doi: 10.1155/2024/5273198. eCollection 2024.
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Aging Dis. 2024 Jun 24;16(3):1414-1437. doi: 10.14336/AD.2024.0282.
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