Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Cell Rep. 2021 Mar 9;34(10):108837. doi: 10.1016/j.celrep.2021.108837. Epub 2021 Feb 23.
Passive transfer of convalescent plasma or serum is a time-honored strategy for treating infectious diseases. Human convalescent plasma containing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently being used to treat patients with coronavirus disease 2019 where clinical efficacy trials are ongoing. Here, we assess therapeutic passive transfer in groups of SARS-CoV-2-infected African green monkeys with convalescent sera containing either high or low anti-SARS-CoV-2 neutralizing antibody titers. Differences in viral load and pathology are minimal between monkeys that receive the lower titer convalescent sera and untreated controls. However, lower levels of SARS-CoV-2 in respiratory compartments, reduced severity of virus-associated lung pathology, and reductions in coagulopathy and inflammatory processes are observed in monkeys that receive high titer sera versus untreated controls. Our data indicate that convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early stages of the disease.
被动输注恢复期血浆或血清是治疗传染病的一种历史悠久的策略。目前，含有针对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 抗体的人恢复期血浆正被用于治疗正在进行临床疗效试验的 2019 年冠状病毒病患者。在这里，我们评估了 SARS-CoV-2 感染的非洲绿猴在接受含有高或低抗 SARS-CoV-2 中和抗体滴度的恢复期血清治疗的各组中的治疗性被动转移。接受低滴度恢复期血清和未治疗对照的猴子之间的病毒载量和病理差异最小。然而，与未治疗对照相比，在接受高滴度血清的猴子中，呼吸道隔室中的 SARS-CoV-2 水平降低，与病毒相关的肺部病理严重程度降低，凝血障碍和炎症过程减少。我们的数据表明，在疾病早期给予高滴度抗 SARS-CoV-2 中和抗体的供体血清，人类恢复期血浆疗法可能是一种有效的策略。
