B Lymphocytes Contribute to Celiac Disease Pathogenesis.
作者信息
Lejeune Thomas, Meyer Celine, Abadie Valérie
机构信息
Department of Microbiology, Infectiology, and Immunology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; Sainte-Justine Hospital Research Centre, Montreal, Quebec, Canada.
Department of Medicine, University of Chicago, Chicago, Illinois.
出版信息
Gastroenterology. 2021 Jun;160(7):2608-2610.e4. doi: 10.1053/j.gastro.2021.02.063. Epub 2021 Mar 2.
Abstract
摘要
相似文献
1
B Lymphocytes Contribute to Celiac Disease Pathogenesis.B淋巴细胞参与乳糜泻的发病机制。
Gastroenterology. 2021 Jun;160(7):2608-2610.e4. doi: 10.1053/j.gastro.2021.02.063. Epub 2021 Mar 2.
2
Local communication among mucosal immune cells in patients with celiac disease.乳糜泻患者黏膜免疫细胞的局部通讯。
Gastroenterology. 2015 May;148(6):1187-94. doi: 10.1053/j.gastro.2015.01.030. Epub 2015 Jan 24.
3
Distinct phenotype of CD4 T cells driving celiac disease identified in multiple autoimmune conditions.在多种自身免疫性疾病中鉴定出驱动乳糜泻的 CD4 T 细胞的独特表型。
Nat Med. 2019 May;25(5):734-737. doi: 10.1038/s41591-019-0403-9. Epub 2019 Mar 25.
4
Turning swords into plowshares: transglutaminase to detoxify gluten.化剑为犁：转谷氨酰胺酶用于麸质解毒
Gastroenterology. 2007 Sep;133(3):1025-8. doi: 10.1053/j.gastro.2007.07.039.
5
TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease.在乳糜泻中，TG2-麦胶蛋白复合物作为麦胶蛋白特异性和转谷氨酰胺酶 2 特异性 B 细胞的抗原。
PLoS One. 2021 Nov 3;16(11):e0259082. doi: 10.1371/journal.pone.0259082. eCollection 2021.
6
Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease.乳糜泻模型食猴中，肠 T 细胞分泌白介素-17 和白介素-22 的能力下降与对麸质敏感的肠病一致。
Clin Immunol. 2013 Apr;147(1):40-49. doi: 10.1016/j.clim.2013.02.012. Epub 2013 Feb 28.
7
Intestinal T-cell responses in celiac disease - impact of celiac disease associated bacteria.乳糜泻中的肠道 T 细胞反应——乳糜泻相关细菌的影响。
PLoS One. 2013;8(1):e53414. doi: 10.1371/journal.pone.0053414. Epub 2013 Jan 9.
8
Celiac disease.乳糜泻
Mol Biotechnol. 2002 Nov;22(3):293-9. doi: 10.1385/MB:22:3:293.
9
T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8.一名患有乳糜泻的DR4、DQ7/DR4、DQ8患者小肠黏膜中的T细胞，在由DQ8呈递时会优先识别麦醇溶蛋白。
Hum Immunol. 1994 Dec;41(4):285-91. doi: 10.1016/0198-8859(94)90047-7.
10
Coeliac disease: dissecting a complex inflammatory disorder.乳糜泻：剖析一种复杂的炎症性疾病。
Nat Rev Immunol. 2002 Sep;2(9):647-55. doi: 10.1038/nri885.
引用本文的文献
1
Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onset.狄氏副拟杆菌定殖对宿主微生物组、代谢组、免疫及糖尿病发病的影响。
J Mol Endocrinol. 2025 Aug 28;75(2). doi: 10.1530/JME-25-0025. Print 2025 Aug 1.
2
Population screening of adults identifies novel genetic variants associated with celiac disease.对成年人进行群体筛查可识别出与乳糜泻相关的新型基因变异。
Sci Rep. 2025 Jun 5;15(1):19764. doi: 10.1038/s41598-025-04421-6.
3
Mendelian Randomization Analysis Reveals the Causal Relationships Between Autoimmune Diseases and Idiopathic Thrombocytopenic Purpura and the Mediating Role of Immune Cells.孟德尔随机化分析揭示自身免疫性疾病与特发性血小板减少性紫癜之间的因果关系以及免疫细胞的中介作用。
Eur J Rheumatol. 2025 Apr 23;12(1):1-7. doi: 10.5152/eurjrheum.2025.24100.
4
New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease.新见解：乳糜泻的基因、 gluten 和免疫发病机制。
Gastroenterology. 2024 Jun;167(1):4-22. doi: 10.1053/j.gastro.2024.03.042. Epub 2024 Apr 24.
5
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.抗原驱动的结肠炎症与原发性硬化性胆管炎中异型增生的发展有关。
Nat Med. 2023 Jun;29(6):1520-1529. doi: 10.1038/s41591-023-02372-x. Epub 2023 Jun 15.
6
IgE-Dependent Allergy in Patients with Celiac Disease: A Systematic Review.乳糜泻患者的 IgE 依赖性过敏：系统评价。
Nutrients. 2023 Feb 16;15(4):995. doi: 10.3390/nu15040995.
7
Profiling of peripheral blood B-cell transcriptome in children who developed coeliac disease in a prospective study.一项前瞻性研究中对患乳糜泻儿童外周血B细胞转录组的分析。
Heliyon. 2023 Jan 21;9(2):e13147. doi: 10.1016/j.heliyon.2023.e13147. eCollection 2023 Feb.
8
Immunopathogenesis and environmental triggers in coeliac disease.乳糜泻的免疫发病机制与环境诱因
Gut. 2022 Jul 25;71(11):2337-49. doi: 10.1136/gutjnl-2021-326257.
9
Injection of prototypic celiac anti-transglutaminase 2 antibodies in mice does not cause enteropathy.在小鼠中注射典型的麦胶蛋白转谷氨酰胺酶 2 抗体不会引起肠病。
PLoS One. 2022 Apr 6;17(4):e0266543. doi: 10.1371/journal.pone.0266543. eCollection 2022.
10
Gluten-free diet exposure prohibits pathobiont expansion and gluten sensitive enteropathy in B cell deficient JH-/- mice.无麸质饮食可防止 B 细胞缺陷 JH-/- 小鼠中的条件致病菌扩张和麸质敏感肠病。
PLoS One. 2022 Mar 24;17(3):e0264977. doi: 10.1371/journal.pone.0264977. eCollection 2022.
本文引用的文献
1
Intestinal Anti-tissue Transglutaminase2 Autoantibodies: Pathogenic and Clinical Implications for Celiac Disease.肠道抗组织转谷氨酰胺酶2自身抗体：对乳糜泻的致病及临床意义
Front Nutr. 2020 May 29;7:73. doi: 10.3389/fnut.2020.00073. eCollection 2020.
2
Autoimmunity provoked by foreign antigens.由外来抗原引发的自身免疫
Science. 2020 Apr 10;368(6487):132-133. doi: 10.1126/science.aay3037.
3
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.IL-15、 gluten 和 HLA-DQ8 驱动乳糜泻中的组织破坏。
Nature. 2020 Feb;578(7796):600-604. doi: 10.1038/s41586-020-2003-8. Epub 2020 Feb 12.
4
European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020.欧洲儿科胃肠病学、肝病学和营养学学会 2020 年乳糜泻诊断指南。
J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):141-156. doi: 10.1097/MPG.0000000000002497.
5
Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease.B 细胞的非抗体分泌功能及其在自身免疫病中的作用。
Annu Rev Cell Dev Biol. 2019 Oct 6;35:337-356. doi: 10.1146/annurev-cellbio-100617-062518. Epub 2019 Mar 18.
6
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease.在乳糜泻患者的炎症性肠组织中，浆细胞是表达 MHC 的最丰富的麦胶肽细胞。
Gastroenterology. 2019 Apr;156(5):1428-1439.e10. doi: 10.1053/j.gastro.2018.12.013. Epub 2018 Dec 26.
7
A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease.一种B细胞基因特征与乳糜泻中麸质诱导的肠道损伤程度相关。
Cell Mol Gastroenterol Hepatol. 2017 Jan 28;4(1):1-17. doi: 10.1016/j.jcmgh.2017.01.011. eCollection 2017 Jul.
8
Integration of genetic and immunological insights into a model of celiac disease pathogenesis.将遗传和免疫学见解整合到乳糜泻发病机制模型中。
Annu Rev Immunol. 2011;29:493-525. doi: 10.1146/annurev-immunol-040210-092915.
Zotero 插件