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B Lymphocytes Contribute to Celiac Disease Pathogenesis.

作者信息

Lejeune Thomas, Meyer Celine, Abadie Valérie

机构信息

Department of Microbiology, Infectiology, and Immunology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; Sainte-Justine Hospital Research Centre, Montreal, Quebec, Canada.

Department of Medicine, University of Chicago, Chicago, Illinois.

出版信息

Gastroenterology. 2021 Jun;160(7):2608-2610.e4. doi: 10.1053/j.gastro.2021.02.063. Epub 2021 Mar 2.

Abstract
摘要

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Intestinal Anti-tissue Transglutaminase2 Autoantibodies: Pathogenic and Clinical Implications for Celiac Disease.
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IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.
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Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease.
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A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease.
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