Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Int J Mol Sci. 2021 Feb 24;22(5):2233. doi: 10.3390/ijms22052233.
The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only the key proteins and their intra- and extracellular crosstalk. These complex interactions will be discussed in relation to cancer development, drug resistance, and stem cell exhaustion. This review will also highlight the tumor-suppressive tuberous sclerosis complex (TSC) mutated, mTOR-hyperactive lung disease of women, lymphangioleiomyomatosis (LAM). We will summarize recent advances in the targeting of these pathways by monotherapy or combination therapy, as well as future potential treatments.
雷帕霉素靶蛋白（mTOR）和无翅型 MMTV 整合位点（Wnt）信号转导网络是进化上保守的哺乳动物生长和细胞发育网络。大多数细胞表达这两条通路中的许多蛋白，本综述将仅简要描述关键蛋白及其细胞内外相互作用。这些复杂的相互作用将与癌症发展、耐药性和干细胞衰竭有关。本综述还将重点介绍抑癌性结节性硬化症复合物（TSC）突变、mTOR 过度活跃的女性肺部疾病淋巴管平滑肌瘤病（LAM）。我们将总结这些通路的单药或联合治疗的靶向治疗的最新进展，以及未来的潜在治疗方法。
