Lung Christie Y K, Abdalla Mohamed M, Chu Chun Hung, Yin Iris, Got Sofiya-Roksolana, Matinlinna Jukka P
Faculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.
Materials (Basel). 2021 Feb 18;14(4):961. doi: 10.3390/ma14040961.
The objectives of the study were (1) to develop a novel multi-element-doped porous 58S bioactive glass coating for titanium implants and (2) to investigate the physiochemical, cell cytotoxic and antibacterial properties of this novel coating for titanium implants.
This study employed the sol-gel method to develop a silver-, cobalt (II) oxide- and titanium dioxide-doped 58S bioactive glass coating. The surface topography and in vitro bioactivity of the new bioactive glass-coated implants were studied using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. The surface nanohardness and coating degradation were evaluated using atomic force microscopy (AFM) and inductively coupled plasma atomic emission spectroscopy (ICP-AES), respectively. The cell cytotoxicity was assessed using cell viability of osteoblast-like mouse cells. The antibacterial property was examined using colony-forming units (CFUs) of the implant coating against .
The multi-element-doped porous 58S bioactive glass-coated titanium implant was synthesized. SEM showed that calcium phosphate was formed on the novel coating but not on the 58S bioactive glass coating. The mean surface nanohardness of the novel coating and the 58S coating were 124 ± 24 and 50 ± 17 MPa, respectively ( < 0.001). ICP-AES showed that the releases of Si, Ca and P ions of the novel coating were significantly higher than that of a 58S bioactive glass-coated implant. No significant difference in cell cytotoxicity was found between the novel coating and the 58S coating ( > 0.1). The mean CFUs of the novel coating and the conventional coating were 120 × 10 and 49 × 10 /mL.
A novel multielement-doped porous bioactive glass coating for titanium implants was developed. The coating displays promising biocompatibility and antibacterial activity.
the coating can be used to improve the clinical success of dental implants for patient care if it shows success in clinical trials.
本研究的目的是（1）为钛植入物开发一种新型的多元素掺杂多孔58S生物活性玻璃涂层，以及（2）研究这种新型钛植入物涂层的物理化学、细胞毒性和抗菌性能。
本研究采用溶胶 - 凝胶法制备了银、氧化钴（II）和二氧化钛掺杂的58S生物活性玻璃涂层。使用扫描电子显微镜（SEM）和能量色散X射线光谱研究了新型生物活性玻璃涂层植入物的表面形貌和体外生物活性。分别使用原子力显微镜（AFM）和电感耦合等离子体原子发射光谱（ICP - AES）评估表面纳米硬度和涂层降解情况。使用成骨样小鼠细胞的细胞活力评估细胞毒性。使用植入物涂层对……的菌落形成单位（CFU）检查抗菌性能。
合成了多元素掺杂多孔58S生物活性玻璃涂层钛植入物。SEM显示在新型涂层上形成了磷酸钙，而在58S生物活性玻璃涂层上未形成。新型涂层和58S涂层的平均表面纳米硬度分别为124±24和50±17 MPa（<0.001）。ICP - AES显示新型涂层中Si、Ca和P离子的释放量明显高于58S生物活性玻璃涂层植入物。新型涂层和58S涂层之间在细胞毒性方面未发现显著差异（>0.1）。新型涂层和传统涂层的平均CFU分别为120×10和49×10/mL。
开发了一种用于钛植入物的新型多元素掺杂多孔生物活性玻璃涂层。该涂层显示出良好的生物相容性和抗菌活性。
如果该涂层在临床试验中取得成功，可用于改善牙科植入物在患者护理中的临床成功率。
