School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
College of Chemistry, Nankai University, Tianjin 300071, China.
Molecules. 2021 Feb 23;26(4):1197. doi: 10.3390/molecules26041197.
In the present study, a sunflower-like nanostructure array composed of a series of synaptic nanoparticles and nanospheres was manufactured through an efficient and low-cost colloidal lithography technique. The primary electromagnetic field contribution generated by the synaptic nanoparticles of the surface array structures was also determined by a finite-difference time-domain software to simulate the hotspots. This structure exhibited high repeatability and excellent sensitivity; hence, it was used as a surface-enhanced Raman spectroscopy (SERS) active substrate to achieve a rapid detection of ultra-low concentrations of Alpha-fetoprotein (AFP). This study demonstrates the design of a plasmonic structure with strong electromagnetic coupling, which can be used for the rapid detection of AFP concentration in clinical medicine.
在本研究中，通过一种高效且低成本的胶体光刻技术制造了一种由一系列突触纳米粒子和纳米球组成的向日葵状纳米结构阵列。还通过有限差分时域软件确定了表面阵列结构的突触纳米粒子产生的主要电磁场贡献，以模拟热点。该结构具有高重复性和出色的灵敏度；因此，它被用作表面增强拉曼光谱（SERS）的活性衬底，以实现对超低浓度甲胎蛋白（AFP）的快速检测。本研究展示了具有强电磁耦合的等离子体结构的设计，可用于临床医学中 AFP 浓度的快速检测。
