Wang Yaxin, Zhu Aonan, Zhang Xiaolong, Zhang Yongjun
Center for Advanced Optoelectronic Materials, School of Material and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
College of Chemistry, Nankai University, Tianjin 300071, China.
Molecules. 2021 Apr 17;26(8):2338. doi: 10.3390/molecules26082338.
Colloidal lithography is an efficient and low-cost method to prepare an ordered nanostructure array with new shapes and properties. In this study, square-shaped and cone-shaped Au nanostructures were obtained by 70° angle deposition onto polystyrene bead array with the diameter of 500 nm when a space of 120 nm is created between the neighbor beads by plasma etching. The gaps between the units decrease when the Au deposition time increases, which leads to the polarized enhanced local field, in agreement with the surface-enhanced Raman scattering spectra (SERS) observations and finite-difference time-domain (FDTD) simulations. When the Au deposition time increased to 5 min, 5 nm gaps form between the neighbor units, which gave an enhancement factor of 5 × 10. The SERS chip was decorated for the detection of the liver cancer cell marker Alpha-fetoprotein (AFP) with the detection limit down to 5 pg/mL.
胶体光刻是一种制备具有新形状和特性的有序纳米结构阵列的高效且低成本的方法。在本研究中，当通过等离子体蚀刻在相邻珠子之间产生120nm的间距时，通过以70°角沉积到直径为500nm的聚苯乙烯珠子阵列上获得了方形和锥形的金纳米结构。随着金沉积时间的增加，单元之间的间隙减小，这导致极化增强的局部场，这与表面增强拉曼散射光谱（SERS）观察结果和时域有限差分（FDTD）模拟结果一致。当金沉积时间增加到5分钟时，相邻单元之间形成5nm的间隙，其增强因子为5×10。对SERS芯片进行了修饰，用于检测肝癌细胞标志物甲胎蛋白（AFP），检测限低至5pg/mL。
