Karakas Didem, Ozpolat Bulent
Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Istinye University, Istanbul 34010, Turkey.
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Noncoding RNA. 2021 Feb 20;7(1):16. doi: 10.3390/ncrna7010016.
Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and post-translational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的非蛋白质编码RNA，它们通过与DNA、mRNA、微小RNA和蛋白质结合发挥作用，并在转录、转录后、翻译和翻译后水平调节基因表达。根据细胞定位，lncRNAs参与广泛的细胞功能，包括染色质修饰、转录激活、转录干扰、支架作用以及翻译机制的调节。本综述重点介绍了lncRNAs在通过调节翻译因子（即eIF4E、eIF4G、eIF4A、4E-BP1、eEF5A）调控蛋白质翻译方面的最新研究，以及参与这一过程的信号通路，及其作为肿瘤抑制因子或肿瘤促进因子的潜在作用。
