长非编码 RNA 参与免疫反应。
Long Non-Coding RNAs Involved in Immune Responses.
机构信息
Radioisotope Centre, The University of Tokyo , Tokyo , Japan.
出版信息
Front Immunol. 2014 Nov 13;5:573. doi: 10.3389/fimmu.2014.00573. eCollection 2014.
Abstract
A large number of human RNA transcripts, which do not encode proteins are defined as non-coding RNAs (ncRNAs). These ncRNAs are divided into two classes of different lengths; short and long ncRNAs. MicroRNAs are a major class of short ncRNAs, ~22 nucleotides in length that regulate gene expression at the post-transcriptional level. Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and play roles in various biological pathways. In this review, we summarize the functions of lncRNAs which regulate immune responses.
摘要
大量不编码蛋白质的人类 RNA 转录本被定义为非编码 RNA（ncRNA）。这些 ncRNA 分为两类不同长度的 ncRNA：短 ncRNA 和长 ncRNA。microRNAs 是短 ncRNA 的主要类别，长度约为 22 个核苷酸，在转录后水平调节基因表达。长非编码 RNA（lncRNA）长度超过 200 个核苷酸，在各种生物途径中发挥作用。在这篇综述中，我们总结了 lncRNA 调节免疫反应的功能。
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本文引用的文献
1
Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation.
RNA. 2014 Jul;20(7):1103-11. doi: 10.1261/rna.043075.113. Epub 2014 May 20.
2
miR-191: an emerging player in disease biology.
Front Genet. 2014 Apr 23;5:99. doi: 10.3389/fgene.2014.00099. eCollection 2014.
3
Effect of aging on microRNAs and regulation of pathogen recognition receptors.
Curr Opin Immunol. 2014 Aug;29:29-37. doi: 10.1016/j.coi.2014.03.006. Epub 2014 Apr 25.
4
The human long noncoding RNA lnc-IL7R regulates the inflammatory response.
Eur J Immunol. 2014 Jul;44(7):2085-95. doi: 10.1002/eji.201344126. Epub 2014 Jun 5.
5
Non-coding RNA interact to regulate neuronal development and function.
Front Cell Neurosci. 2014 Feb 24;8:47. doi: 10.3389/fncel.2014.00047. eCollection 2014.
6
Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli.
Mol Cell. 2014 Feb 6;53(3):393-406. doi: 10.1016/j.molcel.2014.01.009.
7
The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL.
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1002-7. doi: 10.1073/pnas.1313768111. Epub 2013 Dec 26.
8
A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer.
Mol Carcinog. 2015 Jun;54 Suppl 1:E1-E12. doi: 10.1002/mc.22120. Epub 2013 Dec 19.
9
Non-coding RNAs: multi-tasking molecules in the cell.
Int J Mol Sci. 2013 Jul 31;14(8):16010-39. doi: 10.3390/ijms140816010.
10
A long noncoding RNA mediates both activation and repression of immune response genes.
Science. 2013 Aug 16;341(6147):789-92. doi: 10.1126/science.1240925. Epub 2013 Aug 1.
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