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白藜芦醇与平面脂质模型相互作用的研究：对其在脂质双层中位置的深入了解。

Study of Resveratrol's Interaction with Planar Lipid Models: Insights into Its Location in Lipid Bilayers.

作者信息

Meleleo Daniela

机构信息

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", via E. Orabona 4, 70126 Bari, Italy.

出版信息

Membranes (Basel). 2021 Feb 14;11(2):132. doi: 10.3390/membranes11020132.

DOI:10.3390/membranes11020132
PMID:33672841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7918209/
Abstract

Resveratrol, a polyphenolic molecule found in edible fruits and vegetables, shows a wide range of beneficial effects on human health, including anti-microbial, anti-inflammatory, anti-cancer, and anti-aging properties. Due to its poor water solubility and high liposome-water partition coefficient, the biomembrane seems to be the main target of resveratrol, although the mode of interaction with membrane lipids and its location within the cell membrane are still unclear. In this study, using electrophysiological measurements, we study the interaction of resveratrol with planar lipid membranes (PLMs) of different composition. We found that resveratrol incorporates into palmitoyl-oleoyl-phosphatidylcholine (POPC) and POPC:Ch PLMs and forms conductive units unlike those found in dioleoyl-phosphatidylserine (DOPS):dioleoyl-phosphatidylethanolamine (DOPE) PLMs. The variation of the biophysical parameters of PLMs in the presence of resveratrol provides information on its location within a lipid double layer, thus contributing to an understanding of its mechanism of action.

摘要

白藜芦醇是一种存在于可食用水果和蔬菜中的多酚类分子，对人体健康具有广泛的有益作用，包括抗菌、抗炎、抗癌和抗衰老特性。由于其水溶性差且脂质体 - 水分配系数高，生物膜似乎是白藜芦醇的主要靶点，尽管其与膜脂的相互作用方式及其在细胞膜内的位置仍不清楚。在本研究中，我们使用电生理测量方法，研究了白藜芦醇与不同组成的平面脂质膜（PLM）的相互作用。我们发现，白藜芦醇可掺入棕榈酰 - 油酰 - 磷脂酰胆碱（POPC）和POPC:Ch PLM中，并形成与二油酰磷脂酰丝氨酸（DOPS）:二油酰磷脂酰乙醇胺（DOPE）PLM中不同的导电单元。在白藜芦醇存在下PLM生物物理参数的变化提供了其在脂质双层中位置的信息，从而有助于理解其作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/6a96335e7559/membranes-11-00132-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/0e898a7adf1b/membranes-11-00132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/47763491fbeb/membranes-11-00132-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/dc5f21a7f35d/membranes-11-00132-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/c0b45c0a2382/membranes-11-00132-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/c3a6117e83f2/membranes-11-00132-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/6a96335e7559/membranes-11-00132-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/0e898a7adf1b/membranes-11-00132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/47763491fbeb/membranes-11-00132-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/dc5f21a7f35d/membranes-11-00132-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/c0b45c0a2382/membranes-11-00132-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/c3a6117e83f2/membranes-11-00132-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e076/7918209/6a96335e7559/membranes-11-00132-g006.jpg

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