College of Ayurveda, Mount Madonna Institute, 445 Summit Road, Watsonville, CA 95076, USA.
California College of Ayurveda, 700 Zion Street, Nevada City, CA 95959, USA.
Medicina (Kaunas). 2021 Feb 27;57(3):217. doi: 10.3390/medicina57030217.
Artemisia is one of the most widely distributed genera of the family Astraceae with more than 500 diverse species growing mainly in the temperate zones of Europe, Asia and North America. The plant is used in Chinese and Ayurvedic systems of medicine for its antiviral, antifungal, antimicrobial, insecticidal, hepatoprotective and neuroprotective properties. Research based studies point to Artemisia's role in addressing an entire gamut of physiological imbalances through a unique combination of pharmacological actions. Terpenoids, flavonoids, coumarins, caffeoylquinic acids, sterols and acetylenes are some of the major phytochemicals of the genus. Notable among the phytochemicals is artemisinin and its derivatives (ARTs) that represent a new class of recommended drugs due to the emergence of bacteria and parasites that are resistant to quinoline drugs. This manuscript aims to systematically review recent studies that have investigated artemisinin and its derivatives not only for their potent antiviral actions but also their utility against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). : PubMed Central, Scopus and Google scholar databases of published articles were collected and abstracts were reviewed for relevance to the subject matter. : The unprecedented impact that artemisinin had on public health and drug discovery research led the Nobel Committee to award the Nobel Prize in Physiology or Medicine in 2015 to the discoverers of artemisinin. Thus, it is clear that Artemisia's importance in indigenous medicinal systems and drug discovery systems holds great potential for further investigation into its biological activities, especially its role in viral infection and inflammation.
青蒿是菊科蒿属中分布最广的属之一，有 500 多种不同的物种，主要生长在欧洲、亚洲和北美的温带地区。该植物在中医和阿育吠陀医学中被用于其抗病毒、抗真菌、抗菌、杀虫、保肝和神经保护特性。基于研究的研究表明，青蒿通过独特的药理作用组合，在解决一系列生理失衡方面发挥作用。萜类化合物、类黄酮、香豆素、咖啡酰奎宁酸、甾醇和炔烃是该属的一些主要植物化学物质。植物化学物质中值得注意的是青蒿素及其衍生物 (ARTs)，由于对喹啉类药物具有抗药性的细菌和寄生虫的出现，它们代表了一类新的推荐药物。本文旨在系统综述最近的研究，这些研究不仅调查了青蒿素及其衍生物的强大抗病毒作用，还调查了它们对抗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的效用。: 从已发表文章的 PubMed Central、Scopus 和 Google Scholar 数据库中收集了数据，并审查了摘要与主题的相关性。: 青蒿素对公共卫生和药物发现研究产生了前所未有的影响，促使诺贝尔委员会于 2015 年将诺贝尔生理学或医学奖授予青蒿素的发现者。因此，很明显，青蒿在土著医疗系统和药物发现系统中的重要性为进一步研究其生物活性，特别是其在病毒感染和炎症中的作用，提供了巨大的潜力。
