Zhang Zhenbiao, Lei Lei, Zhang Haixia, Dai Hegen, Song Yu, Li Lei, Wang Yang, Xia Zhaofei
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, China Agricultural University, Beijing 100193, China.
Pathogens. 2021 Feb 27;10(3):271. doi: 10.3390/pathogens10030271.
This work is aimed to elucidate the prevalence and characteristics of antimicrobial resistance, virulence, and molecular typing in from clinical companion animals in Beijing, China. In total, 105 (2.0%) isolates were recovered from 5359 samples (dogs, n = 3356; cats, n = 2003). All tested isolates exhibited high resistance to amoxicillin-clavulanate (74.3%). Moreover, resistance rates in dog isolates (2.1%) were significantly higher than in cat isolates (0.9%); however, the rate of multidrug-resistance (MDR) was 57.1% and the MDR prevalence in cats was significantly higher than dogs. Whole-genome sequencing demonstrated plasmids IncX4 and IncFIA (HI1)/FII(K) carried (n = 1) and (n = 1), but (n = 1) and (n = 4) were harbored in IncX3-type plasmids, and the above genes were in different isolates. The most prevalent sequence types (STs) in companion animals were ST1 (n = 9) and ST37 (n = 9). Compared to National Center for Biotechnology Information (NCBI) data on human , resistance genes and were more prevalent in human isolates; however, and showed a higher prevalence in companion animals. Hypermucoviscosity was reported in 9 (8.6%) isolates, whereas 64 isolates (61.0%) were hypervirulent (hvKP) via the . These findings validate the high risk of and necessitate its relevant control in pet clinics.
本研究旨在阐明中国北京临床伴侣动物中抗菌药物耐药性、毒力及分子分型的流行情况和特征。总共从5359份样本（犬3356份；猫2003份）中分离出105株（2.0%）菌株。所有测试菌株对阿莫西林-克拉维酸均表现出高耐药性（74.3%）。此外，犬分离株的耐药率（2.1%）显著高于猫分离株（0.9%）；然而，多重耐药（MDR）率为57.1%，猫的MDR流行率显著高于犬。全基因组测序表明，IncX4和IncFIA(HI1)/FII(K)质粒携带[具体基因1]（n = 1）和[具体基因2]（n = 1），但[具体基因3]（n = 1）和[具体基因4]（n = 4）存在于IncX3型质粒中，且上述基因存在于不同分离株中。伴侣动物中最常见的序列类型（STs）是ST1（n = 9）和ST37（n = 9）。与美国国立生物技术信息中心（NCBI）关于人类[具体细菌名称]的数据相比，耐药基因[具体基因5]和[具体基因6]在人类分离株中更为普遍；然而，[具体基因7]和[具体基因8]在伴侣动物中显示出更高的流行率。9株（8.6%）分离株报告有高黏液性，而64株（61.0%）通过[具体检测方法]为高毒力肺炎克雷伯菌（hvKP）。这些发现证实了[具体细菌名称]的高风险，并需要在宠物诊所进行相关控制。
Zotero 插件
