Department of Pediatric Surgery, Amsterdam UMC, Emma Children's Hospital, University of Amsterdam and Vrije Universiteit Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Department of Radiology and Nuclear Medicine Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Pediatr Surg Int. 2021 Jul;37(7):843-849. doi: 10.1007/s00383-021-04872-8. Epub 2021 Mar 7.
Accurate differentiation between simple and complex appendicitis is important since differences in treatment exist. This study aimed to assess the accuracy of ultrasonography in differentiating between simple and complex appendicitis.
Data from children aged < 18 years who underwent appendectomy between the 1st of January 2013 and the 1st of January 2018 were analyzed retrospectively. Ultrasonography reports of eligible children were divided into simple (test negative) and complex appendicitis (test positive) based on predefined criteria and compared to a gold standard (a combination of predefined perioperative and histopathological criteria). Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) were calculated to measure ultrasonographic accuracy in differentiating between simple and complex appendicitis.
176 children were eligible for inclusion. The mean age at the time of operation was 10.1 ± SD 4.6 years. 84 (47.7%) children had simple appendicitis and 92 (52.3%) had complex appendicitis. The use of ultrasonography yielded a sensitivity: 46%, specificity: 90%, PPV: 84%, and NPV: 60%.
Ultrasonography as standalone modality is not suitable for differentiating between simple and complex appendicitis in children. To improve preoperative differentiation, other variables such as clinical signs and laboratory data are necessary in conjunction with ultrasonography findings.
准确区分单纯性和复杂性阑尾炎非常重要,因为两者的治疗方法存在差异。本研究旨在评估超声检查在区分单纯性和复杂性阑尾炎中的准确性。
回顾性分析了 2013 年 1 月 1 日至 2018 年 1 月 1 日期间接受阑尾切除术的年龄小于 18 岁的儿童的数据。根据预设标准,将符合条件的儿童的超声报告分为单纯性(检测结果为阴性)和复杂性阑尾炎(检测结果为阳性),并与金标准(一组预设的围手术期和组织病理学标准相结合)进行比较。计算敏感性、特异性、阴性预测值(NPV)和阳性预测值(PPV),以衡量超声检查在区分单纯性和复杂性阑尾炎中的准确性。
共有 176 名儿童符合纳入标准。手术时的平均年龄为 10.1 ± 4.6 岁。84 名(47.7%)儿童患有单纯性阑尾炎,92 名(52.3%)儿童患有复杂性阑尾炎。超声检查的敏感性为 46%,特异性为 90%,PPV 为 84%,NPV 为 60%。
超声检查作为单一方法不适合区分儿童的单纯性和复杂性阑尾炎。为了提高术前的区分能力,除了超声检查结果外,还需要结合临床症状和实验室数据等其他变量。