Postgraduate Program in Dentistry, Health Institute of Nova Friburgo (ISNF), Fluminense Federal University (UFF), Nova Friburgo, RJ, Brazil.
Rio de Janeiro Botanical Garden Research Institute, Rio de Janeiro, RJ, Brazil.
Nat Prod Res. 2022 Mar;36(6):1636-1640. doi: 10.1080/14786419.2021.1895148. Epub 2021 Mar 7.
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignancy. Research on essential oils (EOs) has shown important cytotoxic and anti-tumor properties, among others. Piperaceae species are rich in EOs and here we highlight Kunth. We investigated the crude EOs from , their pure major constituents and an enriched fraction with the main EO compounds (EF) as cytotoxic and selective OSCC agents. EOs presented as main compounds (-)-α-pinene, (-)-β-pinene and limonene. EOs showed an IC lower than all isolated compounds, except for (-)-β-pinene in OSCC cells. The (-)-β-pinene induced cell death with apoptotic characteristics. Commercial standards showed greater selectivity than EOs, and (-)-β-pinene was the most selective among them. EF showed higher selectivity compared to crude EOs and carboplatin, turning it into a good candidate as an anticancer fraction. These results are important for the possible development of new treatments for OSCC.
口腔鳞状细胞癌（OSCC）是头颈部恶性肿瘤中最常见的类型。研究表明，精油（EOs）具有重要的细胞毒性和抗肿瘤特性。胡椒科植物富含精油，我们在这里重点介绍 Kunth。我们研究了 的粗精油、它们的纯主要成分以及富含主要精油化合物的富集部分（EF）作为细胞毒性和选择性 OSCC 药物。EOs 的主要成分是（-）-α-蒎烯、（-）-β-蒎烯和柠檬烯。与所有分离化合物相比，除了 OSCC 细胞中的（-）-β-蒎烯外，EOs 的 IC 较低。（-）-β-蒎烯诱导具有凋亡特征的细胞死亡。商业标准比 EOs 具有更高的选择性，而（-）-β-蒎烯在其中是最具选择性的。与粗 EOs 和卡铂相比，EF 表现出更高的选择性，使其成为一种有前途的抗癌药物。这些结果对于开发新的 OSCC 治疗方法具有重要意义。
