红巨藻（sp.）提取物对 UVB 照射小鼠的抗炎作用。
Anti-inflammatory Effect of Red Macroalgae Bulung Sangu (sp.) Extract in UVB-Irradiated Mice.
出版信息
Pak J Biol Sci. 2021 Jan;24(1):80-89. doi: 10.3923/pjbs.2021.80.89.
BACKGROUND AND OBJECTIVE
Bulung Sangu, like many other macroalgae, is a source of beneficial phytochemical for health. This study was aimed to determine the anti-inflammatory effect of bulung sangu ethanol extract cream.
MATERIALS AND METHODS
The compounds of bulung sangu ethanol extract were identified by using gas chromatography. The antioxidant activity of the extract was examined by the DPPH assay. The anti-inflammatory effect was analyzed in vivo against ultraviolet B (UVB) induction through variables of epidermal thickening and epidermal erosion scores.
RESULTS
Our results showed that bulung sangu ethanol extract contained 18 compounds, in which, 11 compounds considered active as antioxidant and/or anti-inflammatory. Cream extract in both concentrations showed scavenging for more than 50%, with a concentration of 10% cream extract exhibited higher antioxidant activity compared to 5%. The in vivo assay showed a reduction of epidermal thickness and epidermal erosion in the application of both concentrations. The concentration of 10% cream extract showed higher reduction compared to 5% with results produced resembling normal.
CONCLUSION
It can be concluded that bulung sangu displayed a potential source for being developed for the health and medicine aspect, especially for various activities supported by antioxidants and anti-inflammatory.
背景与目的
布龙桑果和其他许多大型藻类一样，是有益于健康的植物化学物质的来源。本研究旨在确定布龙桑果乙醇提取物乳膏的抗炎作用。
材料与方法
采用气相色谱法鉴定布龙桑果乙醇提取物中的化合物。通过 DPPH 测定法检测提取物的抗氧化活性。通过表皮增厚和表皮侵蚀评分等变量，分析了对紫外线 B (UVB)诱导的体内抗炎作用。
结果
结果表明，布龙桑果乙醇提取物含有 18 种化合物，其中 11 种化合物被认为具有抗氧化和/或抗炎活性。两种浓度的乳膏提取物均显示出超过 50%的清除率，浓度为 10%的乳膏提取物的抗氧化活性高于 5%。体内试验表明，两种浓度的乳膏提取物均能减少表皮厚度和表皮侵蚀。浓度为 10%的乳膏提取物的降低效果比 5%更高，结果与正常情况相似。
结论
综上所述，布龙桑果可能是一种有潜力的健康和医学应用的资源，特别是在抗氧化和抗炎作用支持的各种活动中。
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