Kong Bin, Liu Rui, Guo Jiahui, Lu Ling, Zhou Qing, Zhao Yuanjin
Department of Cardio-Thoracic Surgery, Institute of Translational Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 210008, Nanjing, China.
Department of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 210008, Nanjing, China.
Bioact Mater. 2022 Apr 25;19:328-347. doi: 10.1016/j.bioactmat.2022.04.016. eCollection 2023 Jan.
Nano/micro fibers have evoked much attention of scientists and have been researched as cutting edge and hotspot in the area of fiber science in recent years due to the rapid development of various advanced manufacturing technologies, and the appearance of fascinating and special functions and properties, such as the enhanced mechanical strength, high surface area to volume ratio and special functionalities shown in the surface, triggered by the nano or micro-scale dimensions. In addition, these outstanding and special characteristics of the nano/micro fibers impart fiber-based materials with wide applications, such as environmental engineering, electronic and biomedical fields. This review mainly focuses on the recent development in the various nano/micro fibers fabrication strategies and corresponding applications in the biomedical fields, including tissue engineering scaffolds, drug delivery, wound healing, and biosensors. Moreover, the challenges for the fabrications and applications and future perspectives are presented.
由于各种先进制造技术的快速发展,以及纳米或微米尺度尺寸引发的迷人且特殊的功能和特性,如增强的机械强度、高比表面积以及表面呈现的特殊功能,纳米/微纤维近年来引起了科学家们的广泛关注,并成为纤维科学领域的前沿和热点研究方向。此外,纳米/微纤维的这些优异和特殊特性赋予了纤维基材料广泛的应用,如环境工程、电子和生物医学领域。本综述主要聚焦于各种纳米/微纤维制造策略的最新进展及其在生物医学领域的相应应用,包括组织工程支架、药物递送、伤口愈合和生物传感器。此外,还介绍了制造和应用面临的挑战以及未来展望。