Jusuf Nelva Karmila, Putra Imam Budi, Sutrisno Angie Regina
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Int J Gen Med. 2021 Mar 1;14:681-686. doi: 10.2147/IJGM.S294509. eCollection 2021.
Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles with polymorphic lesions, consisting of comedones, papules, pustules and nodules with varying degrees of severity. Stress is one of the triggers of acne vulgaris. Peripheral nerves release substance P in response to stress. Substance P causes proliferation and differentiation of sebaceous glands and increases lipid synthesis in sebocytes.
To determine the correlation between stress scale and serum substance P level in acne vulgaris.
This study was an observational analytic study with a cross-sectional design involving 30 patients with acne vulgaris and 30 controls. History taking, dermatological examination and the Holmes-Rahe stress scale questionnaire were performed with each patient to evaluate stress scale, followed by taking blood samples to assess substance P serum levels using the ELISA test. The collected data were analyzed using the Spearman correlation test.
In both groups, the majority of subjects were 23-27 years old (36.7%) and most of them were female (76.7%). The majority in the acne vulgaris group had low scores on the stress scale, represented by 17 patients (56.7%). The main cause of stress in the acne vulgaris group was a major change in sleeping habits (66.7%). In the acne vulgaris group, the highest mean value of serum substance P level in high stress scale group was 168.2 pg/mL. There was a positive correlation between stress scale and serum substance P level in acne vulgaris with moderate strength and this was statistically significant (r = 0.446; p = 0.014). Meanwhile, stress scale and serum substance P level in controls were not correlated and this was not statistically significant (r = -0.090; p = 0.636).
There was a correlation between stress scale and serum substance P level in acne vulgaris.
寻常痤疮是一种毛囊皮脂腺的慢性炎症性疾病，具有多形性损害，包括粉刺、丘疹、脓疱和结节，严重程度各异。压力是寻常痤疮的诱发因素之一。外周神经在应激反应时会释放P物质。P物质会导致皮脂腺增殖和分化，并增加皮脂腺细胞中的脂质合成。
确定寻常痤疮患者压力量表评分与血清P物质水平之间的相关性。
本研究为观察性分析研究，采用横断面设计，纳入30例寻常痤疮患者和30例对照。对每位患者进行病史采集、皮肤科检查及霍尔姆斯-拉赫压力量表问卷调查以评估压力量表评分，随后采集血样，采用酶联免疫吸附测定法检测血清P物质水平。收集的数据采用Spearman相关性检验进行分析。
两组中，大多数受试者年龄在23 - 27岁（36.7%），且大多数为女性（76.7%）。寻常痤疮组中大多数患者压力量表评分较低，有17例患者（56.7%）。寻常痤疮组压力的主要原因是睡眠习惯的重大改变（66.7%）。在寻常痤疮组中，高压力量表评分组血清P物质水平的最高均值为168.2 pg/mL。寻常痤疮患者的压力量表评分与血清P物质水平之间存在中等强度的正相关，且具有统计学意义（r = 0.446；p = 0.）。同时，对照组的压力量表评分与血清P物质水平无相关性，且无统计学意义（r = -0.090；p = 0.636）。
寻常痤疮患者的压力量表评分与血清P物质水平之间存在相关性。
