Maltagliati Silvio, Sieber Stephen, Sarrazin Philippe, Cullati Stéphane, Chalabaev Aïna, Millet Grégoire P, Boisgontier Matthieu P, Cheval Boris
Univ. Grenoble Alpes, SENS, F-38000 Grenoble, France.
Swiss NCCR "LIVES-Overcoming Vulnerability: Life Course Perspectives", University of Geneva, Geneva, Switzerland.
medRxiv. 2021 Mar 1:2021.02.25.21252451. doi: 10.1101/2021.02.25.21252451.
Physical activity has been proposed as a protective factor for COVID-19 hospitalization. However, the mechanisms underlying this association are unclear. Here, we examined the association between physical activity and COVID-19 hospitalization and whether this relationship was explained by other risk factors for severe COVID-19.
We used data from adults aged 50 years and older from the Survey of Health, Ageing and Retirement in Europe. The outcome was self-reported hospitalization due to COVID-19 measured before August 2020. The main exposure was usual physical activity, self-reported between 2004 and 2017. Data were analyzed using logistic regression models.
Among the 3139 participants included in the study (69.3 ± 8.5 years, 1763 women), 266 were tested positive for COVID-19 and 66 were hospitalized. Results showed that individuals who engaged in physical activity more than once a week had lower odds of COVID-19 hospitalization than individuals who hardly ever or never engaged in physical activity (odds ratios = 0.41, 95% confidence interval = 0.22-0.74, = .004). This association between physical activity and COVID-19 hospitalization was explained by muscle strength, but not by other risk factors.
These findings suggest that, after 50 years of age, engaging in physical activity more than once a week is associated with lower odds of COVID-19 hospitalization. The protective effect of physical activity on COVID-19 hospitalization is explained by muscle strength.
体育活动被认为是新冠病毒疾病（COVID-19）住院治疗的一个保护因素。然而，这种关联背后的机制尚不清楚。在此，我们研究了体育活动与COVID-19住院治疗之间的关联，以及这种关系是否由其他严重COVID-19风险因素所解释。
我们使用了来自欧洲健康、老龄化和退休调查中50岁及以上成年人的数据。结果是2020年8月之前自我报告的因COVID-19住院情况。主要暴露因素是2004年至2017年期间自我报告的日常体育活动。使用逻辑回归模型分析数据。
在纳入研究的3139名参与者中（年龄69.3±8.5岁，女性1763名），266人COVID-19检测呈阳性，66人住院。结果显示，每周进行一次以上体育活动的个体比几乎从不或从不进行体育活动的个体COVID-19住院几率更低（比值比=0.41，95%置信区间=0.22 - 0.74，P=.004）。体育活动与COVID-19住院治疗之间的这种关联由肌肉力量所解释，而非其他风险因素。
这些发现表明，50岁以后，每周进行一次以上体育活动与较低的COVID-19住院几率相关。体育活动对COVID-19住院治疗的保护作用由肌肉力量所解释。
