Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.
Laboratory for the Study of Emotion Elicitation and Expression (E3Lab), Department of Psychology, University of Geneva, Geneva, Switzerland.
J Cachexia Sarcopenia Muscle. 2021 Oct;12(5):1136-1143. doi: 10.1002/jcsm.12738. Epub 2021 Aug 6.
Weak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization.
Data from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity.
The study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results.
Muscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
肌肉力量较弱与多种不良健康后果相关。然而，肌肉力量较弱的个体是否因 COVID-19 而住院的风险更高仍不清楚。本研究旨在探讨肌肉力量与 COVID-19 住院之间的独立关联。
使用逻辑模型分析了 50 岁及以上成年人的数据，该模型调整了多种慢性疾病、体重指数、年龄和性别。使用手持测力计在 2004 年至 2017 年期间反复测量握力。2020 年夏季通过自我报告的方式调查了 COVID-19 住院情况，该指标用于评估 COVID-19 的严重程度。
本研究基于欧洲健康、老龄化和退休调查（SHARE），共纳入 3600 名老年人（68.8±8.8 岁，2044 名女性），其中 316 名被检测出严重急性呼吸综合征冠状病毒 2 呈阳性（8.8%），83 名（2.3%）因 COVID-19 住院。结果显示，握力越高，COVID-19 住院的风险越低[握力每增加 1 个标准差的调整比值比（OR）=0.64，95%置信区间（95%CI）=0.45-0.87，P=0.015]。结果还显示，年龄（每增加 10 年的 OR=1.70，95%CI=1.32-2.20，P<0.001）和肥胖（OR=2.01，95%CI=1.00-3.69，P=0.025）与 COVID-19 住院风险的增加相关。使用不同握力测量方法的敏感性分析以及基于罕见事件逻辑回归和不同参与者样本（即 COVID-19 患者）的稳健性分析均与主要结果一致。
肌肉力量是 50 岁及以上成年人 COVID-19 严重程度的独立危险因素。
