Department of Ophthalmology, Huizhou Municipal Central Hospital, Huizhou, China.
Aier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye Hospital, Guangzhou, China.
Sci Rep. 2021 Mar 10;11(1):5536. doi: 10.1038/s41598-021-84937-9.
It is essential to know the normal range of the interocular symmetry of the cornea (ISC) for keratoconus diagnosis and corneal substitutes design. In the present study we investigated the interocular symmetry of corneal biometrics in 6,644 Chinese myopic patients from multiple ophthalmic centers. Corneal biometrics of both eyes were exported from the Pentacam instrument. Interocular symmetry of the corneal biometrics was analyzed by Spearman's correlation test, intraclass correlation coefficient (ICC) analysis and Bland-Altman plot. Significantly strong interocular correlations were found in anterior and posterior corneal curvatures, corneal diameter, corneal thickness, corneal volume, corneal eccentricity, and corneal asphericity (r = 0.87-0.98, all P < 0.001). Moderate interocular correlations were observed in whole corneal astigmatism (r = 0.78) and posterior corneal astigmatism (r = 0.73). ICC between the right and left eyes was 0.94-0.98 for anterior and posterior corneal curvatures, corneal diameter, corneal thickness and corneal volume, 0.80-0.88 for corneal eccentricity and asphericity, and 0.73-0.79 for corneal astigmatism (all P < 0.001). Bland-Altman plot showed that the 95% limit of agreement between both eyes was narrow and symmetric in most of the corneal biometrics, suggesting strong interocular agreements in these corneal biometrics. In conclusion, significant interocular symmetry of corneal biometrics is observed in Chinese myopia patients. Extra attention should be paid to patients with interocular corneal asymmetry.
了解角膜（ISC）的眼间对称性的正常范围对于圆锥角膜的诊断和角膜替代物的设计至关重要。在本研究中，我们调查了来自多个眼科中心的 6644 名中国近视患者的双眼角膜生物测量的眼间对称性。从 Pentacam 仪器导出双眼的角膜生物测量数据。使用 Spearman 相关检验、组内相关系数（ICC）分析和 Bland-Altman 图分析来分析角膜生物测量的眼间对称性。在前部和后部角膜曲率、角膜直径、角膜厚度、角膜体积、角膜偏心度和角膜非球面性方面发现了显著的强眼间相关性（r=0.87-0.98，均 P<0.001）。在全角膜散光（r=0.78）和后角膜散光（r=0.73）方面观察到中度的眼间相关性。右眼和左眼之间的 ICC 为 0.94-0.98，用于前、后部角膜曲率、角膜直径、角膜厚度和角膜体积，0.80-0.88 用于角膜偏心度和非球面性，0.73-0.79 用于角膜散光（均 P<0.001）。 Bland-Altman 图显示，在大多数角膜生物测量中，双眼的 95%一致性界限狭窄且对称，表明这些角膜生物测量中具有很强的眼间一致性。总之，在中国人近视患者中观察到角膜生物测量的显著眼间对称性。对于角膜不对称的患者应格外注意。
