Refractive Surgery Center, Hankou Aier Eye Hospital, Wuhan, China.
Aier Eye Hospital of Wuhan University (Wuhan Aier Eye Hospital), Wuhan, Hubei Province, China.
Sci Rep. 2024 Feb 27;14(1):4720. doi: 10.1038/s41598-024-55318-9.
The interactions between white-to-white corneal diameter (WTW) and other ocular biometrics are important for planning of refractive surgery and understanding of ocular structural changes in myopia, but such interactions are rarely investigated in young myopic adults. This is a retrospective study involving 7893 young myopic adults from five centers. WTW and other ocular biometrics were measured by Pentacam. The ocular biometrics included anterior corneal curvature (AK) and posterior corneal curvature (PK), central corneal thickness (CCT) and corneal volume (CV), anterior and corneal eccentricity and asphericity, anterior corneal astigmatism (ACA) and posterior corneal astigmatism, anterior chamber depth (ACD), and anterior chamber volume (ACV). The ocular biometrics were compared among eyes of different WTW quartiles. Multivariate linear regression was used to assess the linear associations between WTW and other ocular biometrics adjusting for age, gender and spherical equivalent. In eyes of different WTW quartiles, other ocular biometrics were also significantly different (all P < 0.05). After adjusting for age, gender and spherical equivalent, WTW was positively correlated to AK (β = 0.26 to 0.29), ACA (β = 0.13), anterior corneal asphericity (β = 0.05), PK (β = 0.33 to 0.34), posterior corneal asphericity (β = 0.13), ACD (β = 0.29), and ACV (β = 40.69), and was negatively correlated to CCT (β = - 6.83), CV (β = - 0.06 to - 0.78), anterior corneal eccentricity (β = - 0.035), and posterior corneal eccentricity (β = - 0.14) (all P < 0.001). In conclusion, we found that in young myopic adults, larger WTW was associated with thinner corneal thickness, flatter corneal curvature, more anterior corneal toricity, less corneal eccentricity and asphericity, and broader anterior chamber. Our findings may fill in the gap of literature, and help us better understand how the anterior segment structures interact with the WTW in myopia.
角膜直径（WTW）与其他眼部生物测量值之间的相互作用对于屈光手术的规划和近视患者眼结构变化的理解非常重要，但在年轻的近视成年人中，很少有研究关注这种相互作用。这是一项涉及五个中心的 7893 名年轻近视成年人的回顾性研究。使用 Pentacam 测量 WTW 和其他眼部生物测量值。眼部生物测量值包括前角膜曲率（AK）和后角膜曲率（PK）、中央角膜厚度（CCT）和角膜体积（CV）、前角膜和角膜偏心度和非球面性、前角膜散光（ACA）和后角膜散光、前房深度（ACD）和前房容积（ACV）。比较不同 WTW 四分位区间的眼部生物测量值。使用多元线性回归评估 WTW 与其他眼部生物测量值之间的线性关联，调整年龄、性别和等效球镜。在不同 WTW 四分位区间的眼中，其他眼部生物测量值也有显著差异（均 P < 0.05）。在调整年龄、性别和等效球镜后，WTW 与 AK（β=0.26 至 0.29）、ACA（β=0.13）、前角膜非球面性（β=0.05）、PK（β=0.33 至 0.34）、后角膜非球面性（β=0.13）、ACD（β=0.29）和 ACV（β=40.69）呈正相关，与 CCT（β=-6.83）、CV（β=-0.06 至-0.78）、前角膜偏心度（β=-0.035）和后角膜偏心度（β=-0.14）呈负相关（均 P < 0.001）。总之，我们发现，在年轻的近视成年人中，较大的 WTW 与较薄的角膜厚度、较平坦的角膜曲率、更大的前角膜旋度、较小的角膜偏心度和非球面性以及更宽的前房有关。我们的研究结果可能填补了文献空白，有助于我们更好地理解在近视眼中前节结构与 WTW 如何相互作用。
