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戒烟可改善慢性病患者的健康状况:来自中国老年人纵向研究的证据。

Smoking cessation improves health status of patients with chronic diseases: evidence from a longitudinal study of older adults in China.

作者信息

Zhu Haoyu, Xu Peng, Wei Yumeng, Zhao Chuchen, Zhao Danni, Li Yaxin, Ma Xiaobin, Wang Meng, Kang Huafeng

机构信息

The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

出版信息

BMC Public Health. 2025 Mar 11;25(1):957. doi: 10.1186/s12889-025-22203-7.

Abstract

BACKGROUND

Smoking is a well-documented risk factor for numerous chronic diseases, and cessation is correlated with enhanced health outcomes. Nonetheless, the precise effects of smoking cessation on the health status of older adults with chronic conditions in China have not been thoroughly quantified.

OBJECTIVE

This study aims to quantitatively assess the correlations between smoking cessation and enhancements in the health outcomes of elderly Chinese individuals with chronic diseases.

METHOD

This research drew upon data from the China Health and Retirement Longitudinal Study (CHARLS). A cohort of 9914 participants was ultimately included in our analysis. Group comparisons and linear regression analyses were utilized. The investigation delved into health status scores, hematological markers, and physiological parameters.

RESULT

With each additional year of smoking cessation, former smokers demonstrated improved self-rated health and reduced EQ-5D-3L scores. Regression analysis unveiled a positive correlation between smoking cessation and enhanced self-assessed health (β estimate = 0.198), while a notable adverse effect was observed in EQ-5D-3L scores (β estimate = -0.179) and grip strength (β estimate = -2.530). Blood biomarkers also displayed noteworthy relationships with smoking cessation, showcasing rehabilitation in LDL cholesterol, total cholesterol, glucose, cystatin C, creatinine, HbA1c, and uric acid levels.

CONCLUSION

This research provides evidence highlighting the favorable health ramifications associated with smoking cessation in elderly individuals with chronic illnesses. Noteworthy improvements in both subjective health assessments and blood-based markers were observed post-smoking cessation, with benefits becoming more prominent with prolonged abstinence. These results underscore the vital importance of smoking cessation in the holistic care of chronic conditions and broader health enhancement endeavors. Further validation of these findings through an extended follow-up period is anticipated to bolster these conclusions with increased confidence.

摘要

背景

吸烟是众多慢性疾病的一个有充分记录的风险因素,戒烟与健康状况改善相关。尽管如此,在中国,戒烟对患有慢性疾病的老年人健康状况的确切影响尚未得到充分量化。

目的

本研究旨在定量评估戒烟与中国老年慢性病患者健康状况改善之间的相关性。

方法

本研究利用了中国健康与养老追踪调查(CHARLS)的数据。最终,9914名参与者被纳入我们的分析。采用了组间比较和线性回归分析。该调查深入研究了健康状况评分、血液学指标和生理参数。

结果

随着戒烟年限的增加,既往吸烟者的自评健康状况有所改善,EQ-5D-3L评分降低。回归分析显示戒烟与自我评估健康状况的改善之间存在正相关(β估计值 = 0.198),而在EQ-5D-3L评分(β估计值 = -0.179)和握力(β估计值 = -2.530)方面观察到显著的不利影响。血液生物标志物也显示出与戒烟有显著关系,低密度脂蛋白胆固醇、总胆固醇、血糖、胱抑素C、肌酐、糖化血红蛋白和尿酸水平有所恢复。

结论

本研究提供的证据表明,戒烟对患有慢性疾病的老年人有积极的健康影响。戒烟后,主观健康评估和血液指标均有显著改善,且随着戒烟时间延长,益处更为明显。这些结果强调了戒烟在慢性病整体护理和更广泛的健康促进工作中的至关重要性。预计通过延长随访期对这些发现进行进一步验证,将更有信心地支持这些结论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fa4/11895389/f757f6bc0fa9/12889_2025_22203_Fig1_HTML.jpg

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