Li Zi-Hao, Chen Ying, Sun Yunxia, Zhang Xian-Zheng
Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
ACS Nano. 2021 Mar 23;15(3):5189-5200. doi: 10.1021/acsnano.0c10388. Epub 2021 Mar 11.
Developing appropriate photothermal agents to meet complex clinical demands is an urgent challenge for photothermal therapy of tumors. Here, platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high photothermal conversion efficiency, and good antioxidative catalytic activity are developed by one-step reduction. By controlling the doping ratio, PtPB nanozymes exhibit tunable localized surface plasmon resonance (LSPR) frequency with significantly enhanced photothermal conversion efficiency and allow multiwavelength photoacoustic/infrared thermal imaging guided photothermal therapy. Experimental band gap and density functional theory calculations further reveal that the decrement of free carrier concentrations and increase in circuit paths of electron transitions co-contribute to the enhanced photothermal conversion efficiency of PtPB with tunable LSPR frequency. Benefiting from antioxidative catalytic activity, PtPB can simultaneously relieve inflammation caused by hyperthermia. Moreover, PtPB nanozymes exhibited good biosafety after intravenous injection. Our findings provide a paradigm for designing safe and efficient photothermal agents to treat complex tumor diseases.
开发合适的光热剂以满足复杂的临床需求是肿瘤光热治疗面临的紧迫挑战。在此，通过一步还原法制备了具有可调光谱吸收、高光热转换效率和良好抗氧化催化活性的铂掺杂普鲁士蓝（PtPB）纳米酶。通过控制掺杂比例，PtPB纳米酶呈现出可调的局域表面等离子体共振（LSPR）频率，光热转换效率显著提高，并可实现多波长光声/红外热成像引导的光热治疗。实验带隙和密度泛函理论计算进一步表明，自由载流子浓度的降低和电子跃迁电路路径的增加共同促成了具有可调LSPR频率的PtPB光热转换效率的提高。得益于抗氧化催化活性，PtPB可同时缓解热疗引起的炎症。此外，PtPB纳米酶静脉注射后表现出良好的生物安全性。我们的研究结果为设计用于治疗复杂肿瘤疾病的安全高效光热剂提供了范例。
