Kim Jae Heon, Jeong In Gab, Khandwala Yash S, Hernandez-Boussard Tina, Brooks James D, Chung Benjamin I
Department of Urology, Stanford University Medical Center, Stanford, CA, USA.
Department of Urology, Soonchunhyang University Hospital, Soonchuhyang University Medical College, Seoul, Korea.
Int Neurourol J. 2021 Sep;25(3):263-270. doi: 10.5213/inj.2040296.148. Epub 2021 Mar 9.
This study aimed to examine the prevalence of surgery for postprostatectomy incontinence (PI) following minimally invasive surgery compared to conventional open surgery for prostate cancer.
This retrospective cohort study used the Florida State Ambulatory Surgery and State Inpatient Databases, 2008 to 2010, radical prostatectomy (RP) patients were identified using International Classification of Diseases (ICD)-9/10 procedure codes and among this cohort, PI was identified also using ICD-9/10 codes. Surgical approaches included minimally invasive (robotic or laparoscopic) versus open (retropubic or perineal) RP. The primary outcome was the overall prevalence of surgery for PI. The secondary outcome was the association of PI requiring anti-incontinence surgery with the surgical approach for RP.
Among the 13,535 patients initially included in the study (mean age, 63.3 years), 6,932 (51.2%) underwent open RP and 6,603 (49.8%) underwent minimally invasive RP. The overall prevalence of surgical procedures for PI during the observation period among the all patients who had received RP was 3.3%. The rate of PI surgery for patients receiving minimally invasive surgery was higher than that for patients receiving open surgery (4.8% vs. 3.0%; risk difference, 1.8%; 95% confidence interval, 0.3%-3.4%). The adjusted prevalence of PI surgery for patients who had undergone laparoscopic RP was higher than that for those with retropubic RP (8.6% vs. 3.7%).
Among patients undergoing RP for prostate cancer, the prevalence of PI surgery is not negligible. Patients undergoing minimally invasive RP had higher adjusted rates for PI surgery compared to open approaches, which was attributed to high rate of PI surgery following laparoscopic approach and low rate of PI surgery following perineal approach. More studies are needed to establish strategies to reduce the rate of PI surgery after RP.
本研究旨在探讨与传统开放性前列腺癌手术相比,微创手术后前列腺切除术后尿失禁(PI)的手术治疗患病率。
这项回顾性队列研究使用了2008年至2010年佛罗里达州门诊手术和州住院数据库,通过国际疾病分类(ICD)-9/10手术编码识别根治性前列腺切除术(RP)患者,在该队列中,也使用ICD-9/10编码识别PI。手术方式包括微创(机器人或腹腔镜)与开放(耻骨后或会阴)RP。主要结局是PI手术的总体患病率。次要结局是需要抗尿失禁手术的PI与RP手术方式之间的关联。
在最初纳入研究的13535例患者中(平均年龄63.3岁),6932例(51.2%)接受了开放性RP,6603例(49.8%)接受了微创RP。在所有接受RP的患者中,观察期内PI手术治疗的总体患病率为3.3%。接受微创手术的患者PI手术率高于接受开放手术的患者(4.8%对3.0%;风险差异1.8%;95%置信区间0.3%-3.4%)。接受腹腔镜RP的患者PI手术的校正患病率高于耻骨后RP患者(8.6%对3.7%)。
在接受前列腺癌RP的患者中,PI手术的患病率不可忽视。与开放手术相比,接受微创RP的患者PI手术校正率更高,这归因于腹腔镜手术后PI手术率高和会阴手术后PI手术率低。需要更多研究来制定降低RP后PI手术率的策略。