National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Collaborative Innovation Centre of Utilisation of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, Hunan, China.
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, China.
J Nutr Biochem. 2021 Jul;93:108619. doi: 10.1016/j.jnutbio.2021.108619. Epub 2021 Mar 8.
Skeletal muscle (SkM) is essential for body movement, energy metabolism, and material metabolism, and directly influences the quality of human life. Aging, chronic diseases, and strenuous exercise often lead to various health problems associated with SkM, including muscle atrophy, loss of muscle mass and strength, and metabolic disorders. Various natural products (NaPs), mainly resveratrol (RES), quercetin (QUE), ursolic acid (UA), ecdysone (ECD; mainly 20-OH ECD, 20-HE), and vitamin D, have been reported to protect or regulate SkM health. Some of the products are functionally equivalent to sex hormones, and some are even referred to as "plant exercise pills." However, controversy persists regarding the role of NaPs in SkM health. Therefore, this review objectively summarizes the in vivo and vitro biological activities, molecular mechanisms, and clinical research results of studies on NaPs applied in the regulation of SkM health over the past decade. The present review could advance further research on NaPs and SkM health, and facilitate the revelation of new evidence that could facilitate the application of NaPs in ensuring SkM health.
骨骼肌（SkM）是身体运动、能量代谢和物质代谢所必需的，直接影响人类的生活质量。衰老、慢性疾病和剧烈运动常常导致与 SkM 相关的各种健康问题，包括肌肉萎缩、肌肉质量和力量的丧失以及代谢紊乱。各种天然产物（NaPs），主要有白藜芦醇（RES）、槲皮素（QUE）、熊果酸（UA）、蜕皮甾酮（ECD；主要是 20-羟蜕皮甾酮、20-高蜕皮甾酮）和维生素 D，已被报道可保护或调节 SkM 健康。其中一些产品在功能上与性激素相当，甚至被称为“植物运动丸”。然而，关于 NaPs 在 SkM 健康中的作用仍存在争议。因此，本综述客观地总结了过去十年中关于 NaPs 调节 SkM 健康的体内和体外生物学活性、分子机制和临床研究结果。本综述可以促进对 NaPs 和 SkM 健康的进一步研究，并有助于揭示新的证据，促进 NaPs 在确保 SkM 健康中的应用。
