• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Using digital twins in viral infection.在病毒感染中使用数字孪生技术。
Science. 2021 Mar 12;371(6534):1105-1106. doi: 10.1126/science.abf3370.
2
Digital Twins for Multiple Sclerosis.数字孪生在多发性硬化症中的应用。
Front Immunol. 2021 May 3;12:669811. doi: 10.3389/fimmu.2021.669811. eCollection 2021.
3
Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials.虚拟患者、数字孪生和因果疾病模型：为计算机临床试验铺平道路。
Drug Discov Today. 2023 Jul;28(7):103605. doi: 10.1016/j.drudis.2023.103605. Epub 2023 May 3.
4
Virtual Twins: Understanding the Data Required for Model-Informed Precision Dosing.虚拟双胞胎：理解模型指导下精准给药所需的数据
Clin Pharmacol Ther. 2020 Apr;107(4):742-745. doi: 10.1002/cpt.1778. Epub 2020 Feb 14.
5
[Digital twins in cancer research and treatment: A future for personalized medicine].[癌症研究与治疗中的数字孪生：个性化医疗的未来]
Bull Cancer. 2023 Oct;110(10):1085-1087. doi: 10.1016/j.bulcan.2023.07.007. Epub 2023 Sep 1.
6
[Basis and perspectives of artificial intelligence in radiation therapy].[人工智能在放射治疗中的基础与前景]
Cancer Radiother. 2019 Dec;23(8):913-916. doi: 10.1016/j.canrad.2019.08.005. Epub 2019 Oct 20.
7
Artificial intelligence in reproductive medicine: a fleeting concept or the wave of the future?人工智能在生殖医学中的应用：昙花一现的概念还是未来的浪潮？
Fertil Steril. 2020 Nov;114(5):905-907. doi: 10.1016/j.fertnstert.2020.10.002.
8
Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.精准医学时代通过多尺度建模和转化系统生物学增强手术效果：多学科视角
Ann Biomed Eng. 2016 Sep;44(9):2611-25. doi: 10.1007/s10439-016-1596-4. Epub 2016 Mar 25.
9
Modeling human behaviors and reactions under dangerous environment.模拟危险环境下的人类行为和反应。
Biomed Sci Instrum. 2005;41:265-70.
10
Modeling and artificial intelligence approaches to enzyme systems.酶系统的建模与人工智能方法
Fed Proc. 1987 Jun;46(8):2481-4.

引用本文的文献

1
Advances in artificial intelligence and precision nutrition approaches to improve maternal and child health in low resource settings.人工智能和精准营养方法在改善资源匮乏地区母婴健康方面的进展。
Nat Commun. 2025 Aug 18;16(1):7673. doi: 10.1038/s41467-025-62985-3.
2
Machine learning enabled multiscale model for nanoparticle margination and physiology based pharmacokinetics.基于机器学习的纳米颗粒边缘化和生理学药代动力学多尺度模型
Comput Chem Eng. 2025 Jul;198. doi: 10.1016/j.compchemeng.2025.109081. Epub 2025 Mar 9.
3
From virtual to reality: innovative practices of digital twins in tumor therapy.从虚拟到现实：数字孪生在肿瘤治疗中的创新实践
J Transl Med. 2025 Mar 19;23(1):348. doi: 10.1186/s12967-025-06371-z.
4
Control of medical digital twins with artificial neural networks.利用人工神经网络控制医学数字孪生体。
Philos Trans A Math Phys Eng Sci. 2025 Mar 13;383(2292):20240228. doi: 10.1098/rsta.2024.0228.
5
Challenges and opportunities in uncertainty quantification for healthcare and biological systems.医疗保健和生物系统不确定性量化中的挑战与机遇。
Philos Trans A Math Phys Eng Sci. 2025 Mar 13;383(2292):20240232. doi: 10.1098/rsta.2024.0232.
6
An initiative on digital nephrology: the Kidney Imageomics Project.数字肾脏病学倡议：肾脏影像组学项目。
Natl Sci Rev. 2025 Feb 21;12(3):nwaf034. doi: 10.1093/nsr/nwaf034. eCollection 2025 Mar.
7
Digital twin brain simulator for real-time consciousness monitoring and virtual intervention using primate electrocorticogram data.用于使用灵长类动物脑电皮质图数据进行实时意识监测和虚拟干预的数字孪生脑模拟器。
NPJ Digit Med. 2025 Feb 10;8(1):80. doi: 10.1038/s41746-025-01444-1.
8
Challenges and opportunities for digital twins in precision medicine from a complex systems perspective.从复杂系统视角看数字孪生在精准医学中的挑战与机遇
NPJ Digit Med. 2025 Jan 17;8(1):37. doi: 10.1038/s41746-024-01402-3.
9
Optimal control of agent-based models via surrogate modeling.通过代理建模实现基于智能体模型的最优控制。
PLoS Comput Biol. 2025 Jan 14;21(1):e1012138. doi: 10.1371/journal.pcbi.1012138. eCollection 2025 Jan.
10
Complexity data science: A spin-off from digital twins.复杂性数据科学：数字孪生的衍生领域。
PNAS Nexus. 2024 Nov 12;3(11):pgae456. doi: 10.1093/pnasnexus/pgae456. eCollection 2024 Nov.

本文引用的文献

1
Mechanistic Modeling of SARS-CoV-2 and Other Infectious Diseases and the Effects of Therapeutics.SARS-CoV-2 和其他传染病的机制建模及治疗效果。
Clin Pharmacol Ther. 2021 Apr;109(4):829-840. doi: 10.1002/cpt.2160. Epub 2021 Mar 8.
2
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.一种用于上皮组织中急性原发性病毒感染和免疫反应的多尺度、多细胞、时空建模的模块化框架及其在药物治疗时机和有效性方面的应用。
PLoS Comput Biol. 2020 Dec 21;16(12):e1008451. doi: 10.1371/journal.pcbi.1008451. eCollection 2020 Dec.
3
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response.抗病毒治疗的效力和时机是决定 SARS-CoV-2 脱落持续时间和炎症反应强度的决定因素。
Sci Adv. 2020 Nov 20;6(47). doi: 10.1126/sciadv.abc7112. Print 2020 Nov.
4
Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States.与致命性冠状病毒病相关的 SARS-CoV-2 的病理学和发病机制，美国。
Emerg Infect Dis. 2020 Sep;26(9):2005-2015. doi: 10.3201/eid2609.202095. Epub 2020 May 21.
5
Integrating machine learning and multiscale modeling-perspectives, challenges, and opportunities in the biological, biomedical, and behavioral sciences.整合机器学习与多尺度建模——生物学、生物医学和行为科学中的观点、挑战与机遇
NPJ Digit Med. 2019 Nov 25;2:115. doi: 10.1038/s41746-019-0193-y. eCollection 2019.
6
Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes.1 型糖尿病闭环控制的 6 个月随机、多中心试验。
N Engl J Med. 2019 Oct 31;381(18):1707-1717. doi: 10.1056/NEJMoa1907863. Epub 2019 Oct 16.
7
A Century of Diabetes Technology: Signals, Models, and Artificial Pancreas Control.一个世纪的糖尿病技术：信号、模型和人工胰腺控制。
Trends Endocrinol Metab. 2019 Jul;30(7):432-444. doi: 10.1016/j.tem.2019.04.008. Epub 2019 May 28.
8
Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease.动脉瘤的血流动力学变量与川崎病患儿的血栓形成风险相关。
Int J Cardiol. 2019 Apr 15;281:15-21. doi: 10.1016/j.ijcard.2019.01.092. Epub 2019 Jan 28.
9
Patient-Specific Multiscale Modeling of the Assisted Bidirectional Glenn.辅助双向 Glenn 的患者特异性多尺度建模。
Ann Thorac Surg. 2019 Apr;107(4):1232-1239. doi: 10.1016/j.athoracsur.2018.10.024. Epub 2018 Nov 22.
10
Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation.计算效率高的人体全肺气道模型中颗粒输运和沉积的分析。第一部分：理论与模型验证。
Comput Biol Med. 2016 Dec 1;79:193-204. doi: 10.1016/j.compbiomed.2016.10.020. Epub 2016 Oct 27.

Using digital twins in viral infection.

作者信息

Laubenbacher Reinhard, Sluka James P, Glazier James A

机构信息

Department of Medicine, University of Florida, Gainesville, FL, USA.

Department of Intelligent Systems Engineering and Biocomplexity Institute, Indiana University, Bloomington, IN, USA.

出版信息

Science. 2021 Mar 12;371(6534):1105-1106. doi: 10.1126/science.abf3370.

DOI:10.1126/science.abf3370
PMID:33707255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8170388/
Abstract
摘要