Luo Hao, Yin Xue-Qian, Tan Peng-Fei, Gu Zhi-Peng, Liu Zhen-Mi, Tan Lin
College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China.
J Mater Chem B. 2021 Mar 28;9(12):2802-2815. doi: 10.1039/d1tb00109d. Epub 2021 Mar 12.
Over the past decades, the morbidity and mortality caused by pathogen invasion remain stubbornly high even though medical care has increasingly improved worldwide. Besides, impacted by the ever-growing multidrug-resistant bacterial strains, the crisis owing to the abuse and misuse of antibiotics has been further exacerbated. Among the wide range of antibacterial strategies, polymeric antibacterial materials with diversified synthetic strategies exhibit unique advantages (e.g., their flexible structural design, processability and recyclability, tuneable platform construction, and safety) for extensive antibacterial fields as compared to low molecular weight organic or inorganic antibacterial materials. In this review, polymeric antibacterial materials are summarized in terms of four structure styles and the most representative material platforms to achieve specific antibacterial applications. The superiority and defects exhibited by various polymeric antibacterial materials are elucidated, and the design of various platforms to elevate their efficacy is also described. Moreover, the application scope of polymeric antibacterial materials is summarized with regard to tissue engineering, personal protection, and environmental security. In the last section, the subsequent challenges and direction of polymeric antibacterial materials are discussed. It is highly expected that this critical review will present an insight into the prospective development of antibacterial functional materials.
在过去几十年中，尽管全球医疗护理水平不断提高，但病原体入侵导致的发病率和死亡率仍然居高不下。此外，受日益增多的多重耐药细菌菌株影响，抗生素滥用和误用引发的危机进一步加剧。在众多抗菌策略中，与低分子量有机或无机抗菌材料相比，具有多样化合成策略的聚合物抗菌材料在广泛的抗菌领域展现出独特优势（例如，其灵活的结构设计、可加工性和可回收性、可调谐平台构建以及安全性）。在本综述中，聚合物抗菌材料按照四种结构样式以及实现特定抗菌应用的最具代表性的材料平台进行了总结。阐述了各种聚合物抗菌材料所展现出的优势和缺陷，并描述了提升其功效的各种平台的设计。此外，还就组织工程、个人防护和环境安全方面总结了聚合物抗菌材料的应用范围。在最后一部分，讨论了聚合物抗菌材料后续面临的挑战和发展方向。殷切期望这篇批判性综述能为抗菌功能材料的未来发展提供见解。
