IBM Research Europe, Saeumerstrasse 4, Rueschlikon, Switzerland.
Institute for Translational Medicine, Department of Health Sciences and Technology, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8092, Zurich, Switzerland.
Angew Chem Int Ed Engl. 2021 Aug 9;60(33):17784-17796. doi: 10.1002/anie.202101316. Epub 2021 Apr 7.
Medication adherence is a medical and societal issue worldwide, with approximately half of patients failing to adhere to prescribed treatments. The goal of this Minireview is to examine how recent work on microfluidics for point-of-care diagnostics may be used to enhance adherence to medication. It specifically focuses on capillary microfluidics since these devices are self-powered, easy to use, and well established for diagnostics and drug monitoring. Considering that an improvement in medication adherence can have a much larger effect than the development of new medical treatments, it is long overdue for the research communities working in chemistry, biology, pharmacology, and material sciences to consider developing technologies to enhance medication adherence. For these reasons, this Minireview is not meant to be exhaustive but rather to provide a quick starting point for researchers interested in joining this complex but intriguing and exciting field of research.
药物依从性是一个全球性的医学和社会问题,大约有一半的患者无法遵循规定的治疗方案。本篇综述的目的是探讨最近用于即时诊断的微流控技术如何用于提高药物依从性。它特别关注毛细管微流控,因为这些设备具有自供电、易于使用且在诊断和药物监测方面得到了很好的应用。考虑到改善药物依从性的效果可能比开发新的医疗方法更大,从事化学、生物学、药理学和材料科学研究的研究人员早就应该考虑开发技术来提高药物依从性。出于这些原因,本篇综述并非详尽无遗,而是为有兴趣加入这一复杂但引人入胜和令人兴奋的研究领域的研究人员提供一个快速的起点。