Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China; Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, PR China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China; Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, PR China.
Breast. 2021 Jun;57:36-42. doi: 10.1016/j.breast.2021.02.012. Epub 2021 Mar 2.
Loss to follow-up (LTFU) during post-operative surveillance of breast cancer patients is detrimental. The pattern of LTFU and its risk factors in Chinese breast cancer patients remains unknown.
Eligible non-metastatic breast cancer patients who underwent surgery at our institution between 2009 and 2012 were included. The clinicopathological features, as well as the LTFU status, were retrieved from the REDCap database. LTFU was defined as the absence of patients for at least 12 months since her last contact. 5-year LTFU was defined as the LTFU status of each patients at 5 years after surgery. The incidence and potential risk factors of LTFU were analyzed. A LTFU-risk score was developed to quantify the risk of LTFU.
A total of 1536 patients with breast cancer were included, and 411(26.8%) patients were 5-year LTFU. 198 patients were LTFU in the first year. Univariate and multivariate analysis revealed that age (younger and older), a lack of medical insurance, longer distance from residence to the hospital, pathology (DCIS/Paget's/Phyllodes), lymph node metastasis, the absence of endocrine therapy and fewer than five contact numbers were significantly and independently associated with the risk of LTFU. A LTFU-risk score was developed and was predictive of LTFU.
A series of risk factors were significantly associated with post-operative LTFU of breast cancer patients. Patients with different risks of LTFU could possibly be identified, and surveillance plans could be individualized for different patients, so as to effectively reduce the overall LTFU rate, and optimize the allocation of medical resources.
乳腺癌患者术后随访失访（LTFU）是有害的。中国乳腺癌患者的 LTFU 模式及其危险因素尚不清楚。
纳入 2009 年至 2012 年在我院接受手术的非转移性乳腺癌患者。从 REDCap 数据库中检索患者的临床病理特征和 LTFU 状态。LTFU 定义为患者自最后一次接触以来至少 12 个月未就诊。5 年 LTFU 定义为患者术后 5 年的 LTFU 状态。分析 LTFU 的发生率及潜在危险因素。建立 LTFU 风险评分来量化 LTFU 的风险。
共纳入 1536 例乳腺癌患者，411 例（26.8%）患者发生 5 年 LTFU。198 例患者在第一年失访。单因素和多因素分析显示，年龄（年轻和年长）、缺乏医疗保险、居住地到医院的距离较远、病理（DCIS/Paget's/Phyllodes）、淋巴结转移、缺乏内分泌治疗和联系号码少于 5 个与 LTFU 风险显著相关。建立了 LTFU 风险评分，并具有预测 LTFU 的能力。
一系列危险因素与乳腺癌患者术后 LTFU 显著相关。可以识别出具有不同 LTFU 风险的患者，并为不同患者制定个体化的监测计划，从而有效降低总体 LTFU 率，优化医疗资源配置。
